Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 163706-06-7
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
163706-06-7 |
Appearance :: |
White Powder |
Molecular Formula:: |
C17H25Cl2F3N5O12P3S2 |
Molecular Weight: |
: 776.359 |
EINECS NO:: |
N/A |
MDL NO:: |
MFCD09837758 |
CAS NO:: |
163706-06-7 |
Appearance :: |
White Powder |
Molecular Formula:: |
C17H25Cl2F3N5O12P3S2 |
Molecular Weight: |
: 776.359 |
EINECS NO:: |
N/A |
MDL NO:: |
MFCD09837758 |
Product Description:
Product Name: Cangrelor CAS NO: 163706-06-7
Synonyms:
[dichloro-[[[(2R,3S,4R,5R)-3,4-dihydroxy-5-[6-(2-methylsulfanylethylamino)-2-(3,3,3-trifluoropropylsulfanyl)purin-9-yl]oxolan-2-yl]metho xy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]methyl]phosphonic acid;
Chemical & Physical Properties:
Appearance : White powder
Assay :≥99.0%
Density:2.087g/cm3
Boiling Point:979.0℃ at 760 mmHg
Flash Point:545.882℃
Cangrelor (trade name Kengreal in the US and Kengrexal in Europe) is a P2Y12 inhibitor FDA approved as of June 2015 as an antiplatelet drug for intravenous application. Some P2Y12 inhibitors are used clinically as effective inhibitors of adenosine diphosphate-mediated platelet activation and aggregation. Unlike clopidogrel (Plavix), which is a prodrug, cangrelor is an active drug not requiring metabolic conversion.
Poor interim results led to the abandonment of the two CHAMPION clinical trials in mid-2009. The BRIDGE study, for short term use prior to surgery, continues. The CHAMPION PHOENIX trial was a randomized study of over 11,000 patients published in 2013. It found usefulness of cangrelor in patients getting cardiac stents. Compared with clopidogrel given around the time of stenting, intravenous ADP-receptor blockade with cangrelor significantly reduced the rate of stent thrombosis and myocardial infarction. Reviewers have questioned the methodology of the trial.
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