Sirolimus CAS 53123-88-9

Product Description:

Product Name: Sirolimus CAS NO: 53123-88-9

Synonyms:

Rapamycin;

23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine;

Chemical & Physical Properties:

Appearance: White to light yellow powder

Assay :≥99.0%

Density:1.18 g/cm3

Boiling Point:973℃ at 760 mmHg

Flash Point:542.3℃

Melting Point:183-185℃

Rapamycin (RAPA) is a new type of macrolide immunosuppressant. It is soluble in organic solvents such as methanol, ethanol, aceto ne, and chloroform. It is very slightly soluble in water and almost insoluble in eth er.

It was developed as early as the 1970s. It was initially used as a low-toxicity antifungal drug. In 1977, it was found to have immunosuppressive effects. In 1989, RAPA was tried as a new drug for the treatment of organ transplant rejection. From animal experiments and In terms of clinical application, it is a new type of immunosuppressant with good curative effect, low toxicity and no nephrotoxicity.

Now it is often used as a drug to maintain the immunity of transplanted organs (especially kidney transplants) to slow down the immune rejection after organ transplantation. However, scientists have recently discovered another use: it can be used to treat Alzheimer’s disease (senile dementia).

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