3-Chloro-5-Hydroxybenzoic Acid CAS 53984-36-4 Fine Chemical Products

Product Description:

Product Name: 3-Chloro-5-hydroxybenzoic acid CAS NO: 53984-36-4

Synonyms:

5-Chloro-m-salicylic Acid;3-chloro-5-hydroxy BA;

Benzoic acid, 3-chloro-5-hydroxy-;

GPR81 Agonist, 3Cl-5OH-BA;

Chemical & Physical Properties:

Appearance: White to beige powder

Assay :≥99.0%

Density: 1.536 g/cm3

Boiling Point: 364.805℃ at 760 mmHg

Melting point: 244.0 to 248.0 ℃

Flash Point: 174.428℃

Storage temp.: Sealed in dry,Room Temperature

Solubility: DMSO: soluble15mg/mL (clear solution)

Safety Information:

HS Code: 2918290000

Caution Statement: P261; P280; P305 + P351 + P338

Signal Word: Danger

Symbol: GHS05, GHS07

Hazard Declaration: H302; H315; H318; H335

5-Chloro-m-salicylic Acid was studied as a potential selective lactate receptor (GPR81) agonists with antilipolytic effects. GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 μM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.

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