Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 53984-36-4
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
53984-36-4 |
Appearance:: |
White To Beige Powder |
Molecular Formula:: |
C7H5ClO3 |
Molecular Weight:: |
172.56600 |
EINECS NO:: |
803-932-3 |
MDL NO:: |
MFCD04114327 |
CAS NO:: |
53984-36-4 |
Appearance:: |
White To Beige Powder |
Molecular Formula:: |
C7H5ClO3 |
Molecular Weight:: |
172.56600 |
EINECS NO:: |
803-932-3 |
MDL NO:: |
MFCD04114327 |
Product Description:
Product Name: 3-Chloro-5-hydroxybenzoic acid CAS NO: 53984-36-4
Synonyms:
5-Chloro-m-salicylic Acid;3-chloro-5-hydroxy BA;
Benzoic acid, 3-chloro-5-hydroxy-;
GPR81 Agonist, 3Cl-5OH-BA;
Chemical & Physical Properties:
Appearance: White to beige powder
Assay :≥99.0%
Density: 1.536 g/cm3
Boiling Point: 364.805℃ at 760 mmHg
Melting point: 244.0 to 248.0 ℃
Flash Point: 174.428℃
Storage temp.: Sealed in dry,Room Temperature
Solubility: DMSO: soluble15mg/mL (clear solution)
Safety Information:
HS Code: 2918290000
Caution Statement: P261; P280; P305 + P351 + P338
Signal Word: Danger
Symbol: GHS05, GHS07
Hazard Declaration: H302; H315; H318; H335
5-Chloro-m-salicylic Acid was studied as a potential selective lactate receptor (GPR81) agonists with antilipolytic effects. GPR81, also known as hydroxycarboxylic acid receptor 1 (HCAR1), is a recently de-orphanized receptor that is activated by lactic acid (EC50 ~ 1.5 mM) but not by other hydroxycarboxylic acids. 3-chloro-5-hydroxy Benzoic Acid (3-chloro-5-hydroxy BA) is an agonist of GPR81 (EC50 = 16 μM) that is inactive against the related GPR109a (HCAR2) receptor. It is similarly effective at GPR81 receptors from a variety of mammalian species and is bioavailable, stimulating lipolysis (increased serum free fatty acids) in mice fed high fat chow for 10 weeks. 3-chloro-5-hydroxy BA, like lactate, blocks basal ghrelin secretion by primary gastric mucosal cells.
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