Chenodeoxycholic Acid CAS 474-25-9 high purity 98%+

Product Description:

Product Name: Chenodeoxycholic acid CAS NO: 474-25-9

Synonyms:

Cholan-24-oic acid, 3,7-dihydroxy-, (3α,5β,7α)-;

3α,7α-Dihydroxy-5β-cholanic Acid;

anthropododesoxycholicacid;

Chemical & Physical Properties:

Appearance: White to off-white powder

Assay :≥96.00%

Density: 1.128g/cm3

Boiling Point: 547.1℃ at 760 mmHg

Melting Point: 167-171℃

Flash Point: 298.8℃

Water Solubility: PRACTICALLY INSOLUBLE

Safety Information:

RTECS: FZ1980000

Safety Statements: S36/37-S45

HS Code: 2918990090

WGK Germany: 2

Risk Statement: R63

Hazard Code: Xn

Application:

Chenodeoxycholic acid (also known as chenodesoxycholic acid, chenocholic acid and 3α,7α-dihydroxy-5β-cholan-24-oic acid) is a bile acid. It occurs as a white crystalline substance insoluble in water but soluble in alcohol and acetic acid,Salts of this carboxylic acid are called chenodeoxycholates. Chenodeoxycholic acid is one of the main bile acids produced by the liver.

It was first isolated from the bile of the domestic goose, which gives it the "cheno" portion of its name (Greek: χήν = goose).

Chenodeoxycholic acid and cholic acid are the two primary bile acids in humans. Some other mammals have muricholic acid or deoxycholic acid rather than chenodeoxycholic acid.

Chenodeoxycholic acid is synthesized in the liver from cholesterol by a process which involves several enzymatic steps. Like other bile acids, it can be conjugated in the liver with taurine or glycine, forming taurochenodeoxycholate or glycochenodeoxycholate. Conjugation results in a lower pKa. This means the conjugated bile acids are ionized at the usual pH in the intestine and will stay in the gastrointestinal tract until reaching the ileum where most will be reabsorbed. Bile acids form micelles which facilitate lipid digestion. After absorption, they are taken up by the liver and resecreted, so undergoing an enterohepatic circulation. Unabsorbed chenodeoxycholic acid can be metabolised by bacteria in the colon to form the secondary bile acid known as lithocholic acid.

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