Send Message
Hefei Home Sunshine Pharmaceutical Technology Co.,Ltd
products
Cases
Home >

China Hefei Home Sunshine Pharmaceutical Technology Co.,Ltd Company Cases

Excess damage for health preservation

​     Excess damage for health preservation   Used for emotional health preservation.   The human body is a conductive body composed of positive and negative charges of bioelectricity. Under the influence of emotions and other factors, bioelectricity changes, causing various disturbances and leading to discomfort.   Silver is the best conductor of electricity. Imagine a thick bundle of silver wire appearing, passing through your body, with the upper end piercing through your head into the void, and the lower end piercing into the ground.   Concentrate on continuously imagining the head, shoulders, upper body, and limbs, and disrupt the flow of electric current along the silver wire bundle, guiding it into the void and releasing it to the earth. The number of times is unlimited, and the body returns to balance. This is a universal guide.   Imagine a thick bundle of silver wire appearing, piercing through one's body, with the upper end piercing through the head and plunging into the void, and the lower end plunging into the ground.   Concentrate on continuously imagining the head, shoulders, upper body, and limbs, and disrupt the flow of electric current along the silver wire bundle, guiding it into the void and releasing it, with no limit on the number of times.   Imagine a thick bundle of silver wire appearing, piercing through one's body, with the upper end piercing through the head and plunging into the void, and the lower end plunging into the ground.   Concentrate on continuously imagining the head, shoulders, upper body, and limbs, and disrupt the flow of electric current along the silver wire bundle, guiding it into the void and releasing it, with no limit on the number of times.   Please remember, this silver wire must penetrate the sky and the earth, piercing the void above and the earth below. As soon as you stand up like this silver wire, it's like the magnetic poles of the earth. Naturally, your body's bioelectricity is positive when it goes up and negative when it goes down. This is automatic, no need to work hard. As soon as you place the silver wire upright, its positive and negative poles will automatically appear. So what about the silver wire that sticks out of the top of the head, it will radiate into the void, and the bottom negative pole will just dock with the earth.   If everyone is willing, they can also tie the silver wire on their heads into the moon, imagining tying it into the full moon. Why? Is it the positive pole above? The moon is too dark, so it's neutralizing; The silver wire below pierces into the center of the earth, which is hot at the center of the earth. Isn't the negative pole below neutralized with the earth's geothermal energy. It's just that you feel very uncomfortable. It's slow when you dive into the void, but very fast when you dive directly into the full moon and the center of the earth. This is its principle.     ​   Practical Q&A on Excess Loss 1. If practicing while sitting, with legs at a right angle to the upper body and silver wire bundles running down from the top of the head, do we need to bend at the waist and then lead downwards? Answer: No need, directly penetrate underground   2. How can we better imagine the direction of the silver wire bundle when practicing lying down, from head to toe? Answer: Imagine plunging into the wall   3. After thinking about the silver wire bundle, do you need to think about how to conduct the current at the same time? Or did it automatically scroll down? Answer: After thinking about the silver wire bundle, I also want to guide the current into the silver wire   4. If you want to guide your body with cold, dampness, toxins, etc., is that okay? Answer: You can think of your own body's cold, dampness, toxins, etc., and guide them together   5. Continuously imagining can be difficult for a while, and it's easy to lose focus. Sometimes, it can even get to the point of breathing. How can one maintain focus? Answer: It's okay to run away, pull it back and keep thinking   6. Can it be imagined at any time? Answer: You can imagine it at any time   7. Can you help the child think? Answer: We cannot help children think ​

Emotional health model

    Emotional health model   Emotions are different emotional responses of the body to external environmental stimuli. In traditional Chinese medicine, human psychological activities are collectively referred to as emotions, which are the comprehensive reflection of human instincts when people come into contact with and understand objective things. Reasonable psychological health care is an important part of human health and has significant value in life. It has been noticed by humans since ancient times.   In daily life, study, and work, people are influenced by various human and material factors, resulting in emotional reactions, negative physical and mental effects, and unhealthy psychological and physiological health. So it's important to maintain emotional and mental health. 1. Relax. Practice relaxation and health preservation to alleviate emotional influences. 2. Mess up. When emotions are influenced by external factors, repeatedly saying to oneself: it's not a big deal, it's not a big deal. Disrupting negative impacts. 3. Anyway. To mitigate the negative impact, search for antonyms, repeatedly say this positive word to oneself, undergo emotional transformation, and return positive and negative to zero. 4. Beyond. When negatively affected, immediately use the three quantity thinking model to absorb the stock, positive and negative variables, and supplementary increment as nutrients, forming an innovative increment that transcends the lower level. Emotions go from producing toxins to producing benefits.   First Flow: Relax 1-9 Second flow: Chaotic 1-9 Third stream: Anyway, 1-9 Fourth Stream: Beyond 1-9

New Era Natural Health Exercise-Health Treasure in the Internet Age

​ Natural Health Exercise   Natural health exercises are designed with 10 movements based on the body's natural operating state.   By using the simplest physical actions, it helps the human body restore its original, natural abilities, unblock the three burners, promote the circulation of qi and blood in the five organs, and enhance the body's vitality, immunity, and self-healing ability.   From the perspective of "restoring the foundation" of the human body, a set of exercise methods based on the principles of traditional Chinese and Western medicine, known as "minimum work and maximum energy efficiency", has been developed.   When the immune system is low, it is recommended to do natural health exercises 2-3 times a day for 30 minutes each time, with a fixed time every day, to form a good biological clock. Persisting in doing exercises, connecting the entire body and mind qi and blood circulation, is very helpful in enhancing immunity and activating self-healing ability.     https://youtu.be/5DZgzj-l0LY?si=27eWECpH4aPntrP1     In the Internet era, people's living standards have improved. They eat too much and have too much nutrition. However, due to less physical activity, people generally suffer from indigestion and poor transportation. Moreover, due to the constantly accelerating pace of life and production, one needs to read a large amount of data, receive and process a large amount of information every day, engage in excessive brain activity, anxiety, stress, and irregular sleep patterns, resulting in excessive blood and qi circulation in brain areas and insufficient blood and qi circulation in the five organs and peripheral limbs. Long term slowing, obstruction, and imbalance of the human circulation can trigger various physical and mental dysfunction diseases. For example, dizziness, tinnitus, dry mouth and eyes, hearing loss, mental distress, restlessness, fear of cold and heat, cold lower limbs, neurasthenia, insomnia, endocrine disorders, and other conditions.   Internet health cognition tells us that human body is a complex and balanced organism evolved from, and health is an inherent ability of human. However, due to the above situation, human health gradually deviates from our body's original abilities and circulation, and the functions of various systems in the human body are insufficient (or abnormal), resulting in insufficient (or defective) overall circulation.   Starting from the characteristics of the Internet era, the natural health exercises are a set of "minimum work and maximum energy efficiency" exercise methods formed from the perspective of the "consolidation and restoration" of the human body according to the principles of traditional Chinese medicine and western medicine. Through the simplest actions, they help the human body recover its original, original and natural abilities and its systematic circulation, and improve human vitality, immunity and self-healing ability.   The scale of natural health exercises is shown in the table below, divided into ten sections. The first three sections regulate the lower and lower regions, including the intestines, kidneys, bladder, and other internal organs, as well as the peripheral nerves from the lower body of the human body to the feet; The middle three sections regulate the central burner and smooth the flow of qi and blood up and down; The last three sections regulate the upper focus and above areas, including all parts of the heart, lungs, and head; The last section is to gather momentum and connect the body's qi and blood.   The specific exercises for health preservation are as follows:   1. Abdominal breathing triple opening method   Knee open, cross open, shoulder open The body naturally opens up Breathing naturally sinks Natural abdominal breathing   The human body is like a hinge, with the spine as the axis of the hinge, the left and right sides of the body as the two sides of the hinge, and the knees, spans, and shoulders as the edges of the two sides of the hinge. By opening the knees, legs, and shoulders, the body opens up like a hinge, and breathing automatically sinks to the abdomen, forming abdominal breathing. This allows the kidneys, the "boiler" of the human body, to reignite and drive the circulation of qi and blood throughout the body, providing a foundation for subsequent circulation.   Action essentials: Stand upright naturally, spread your feet apart naturally, shoulder width apart, feel a rope above your head lifting your body, place your tongue against your palate, and slightly retract your lower jaw.   The first step is to open your knees. Keep your feet parallel and shoulder width apart, slightly release your knees to both sides, do not squat directly, do not squat too much, focus on your feet, and draw qi and blood to your calves and feet.   Step two, spread your hips. Loosen your hips slightly to both sides, and use your hands to slightly pull apart your hips. Qi and blood flow to the reproductive and digestive systems, and sitting down at the tail end feels like sitting on a chair, stretching and stretching your spine. Step three, shoulder up. Place your hands on your waist, slowly release your shoulders to both sides, and experience the human body like two hinges opening to both sides, breathing in a straight line. Close your eyes slightly and breathe naturally for 3 minutes. Mnemonic: straight, open, loose, empty, still.   Benefits: Create natural abdominal breathing, regulate qi and blood, effectively increase oxygen supply to the brain, help relax the mind, alleviate migraine, cold hands and feet, obesity and other problems.   Schematic diagram of three opening method     2. Respiratory smelting method   First pump of oral and nasal breathing Second pump of abdominal breathing Strong stimulation of qi and blood circulation Full body transportation is guaranteed   Continue to use physical movements to activate the second pump of breathing, ensuring the circulation of qi and blood throughout the body.   Action essentials: Stand naturally with feet parallel and shoulder width apart. Deflate your stomach, contract towards your spine, and exhale forcefully until all the air is expelled. Then relax your stomach, take a deep breath, and forcefully inflate your belly. Breathe and inhale once, at least 36 times. It can be done anytime, anywhere.   Benefits: With enough breathing, there is enough energy to promote the circulation of the five organs and six viscera in the body. In addition, the respiratory smelting method can also help strengthen the kidneys, combat anemia, aid in detoxification, and activate cellular functions.   Schematic diagram of breathing smelting method   3. Tonghua Mixing Method   The Milky Way rotates and revolves Self improvement, perseverance, and strong hiking The belly contains a sea of qi and blood Tonghua stirs up qi and blood, making it abundant   On the basis of the operation of qi and blood, it is necessary to integrate the functions of the stomach and kidney. By kneading and stirring, the stomach, intestines, and lower energizer can be fully activated, just like "cooking porridge", to ensure that the food you eat is fully digested, nutrition is absorbed, and dross is discharged.   Action essentials: Stand naturally with feet parallel and shoulder width apart. Rub your hands together and place them on your belly button. Start massaging your abdomen in a clockwise direction, starting from the inside out in small circles to the big circle, and then from the outside in large circles to the small circle, all the way back to your belly button. Stir vigorously 36 times without stopping or changing hands in between. Stir your stomach thoroughly with both hands, and the circle can be made larger to take care of all the internal organs. You can do it standing or lying in bed.   Benefits: Promote digestion and absorption, strengthen the spleen and stomach, improve the utilization rate of diet, and alleviate bad breath; Defeat and reduce excess fat on the stomach; Improve sleep quality.   Schematic diagram of Tonghua mixing method   4. Imagining Wings   Birds fly in the sky High vision, broad mind, and broad mindedness Imagine wings taking me flying Yidai Qi and Blood Jiaoba   The middle burner is the connecting part between the upper and lower parts of the human body, which is the channel for the flow of qi and blood, and is prone to narrowing and blockage. If the channel is blocked and the brain is constantly thinking, and qi and blood are concentrated in the head for a long time, it will cause heat in the upper part and cold in the lower part. So we need to use arm swinging and imagination to open up the middle focus pathway for lifting and entering.   Action essentials: Stand naturally with feet parallel and shoulder width apart. Imagine your arms as your own wings, and lift them horizontally around your spine. Imagine the power of flying with your wings, flapping your arms up and down. When walking uphill, feeling down, encountering difficulties, or facing setbacks in one's career, one can use the wings of imagination to bring joy to one's mood.   Benefits: Adjusting mood, overcoming dark moods, and improving depression; Long term use can make one feel happy, have quick thinking, effectively improve breast diseases, and alleviate hunchback problems.   Imagine a schematic diagram of wings     5. Big swing arm   The waves of the sea rise and fall Drive the vitality of the ocean Swing your arms and move your body Reciting the old and embracing the new brings endless vitality   Action essentials: Stand naturally with feet parallel and shoulder width apart.   The first step is to swing in parallel. Relax your arms, use both hands to move them back and forth naturally, with the amplitude as large as possible. When swinging, keep your hands facing each other, palms inward, and fingertips straight.   Step two, cross toss. Relax your arms, use both hands to move your arms, and swing them back and forth naturally. Keep your palms inward and fingertips straight when swinging.   It can be done while standing or walking, and can be practiced at any time and place. Practice for a total of 30 minutes per day and swing your arm more than 1500 times for better results.   Benefits: Activate the human energy system, activate the three burners, unblock the mammary gland, lower the three highs, regulate endocrine function, improve fatigue, dizziness, and night sweats.   Schematic diagram of large swing arm   6. Radiant spirit   Stand up with the spine as the axis Swing your arms and start moving Balance left and right, turn around Smiling with a refreshed spirit   Action essentials: Stand naturally with feet apart, shoulder width apart. The spine and waist rotate left and right, driving the arms to naturally swing upwards and diagonally, and the head and body twist in sync. Continuously and naturally rotate left and right. Be careful not to rotate too quickly to prevent dizziness.   Benefits: Improve cervical discomfort, protect the spine, make oneself energetic, and resist fatigue.   Spiritual Revitalization Diagram     7. stomp your feet and follow   Inflammation caused by virtual fire Floating yang in the brain Stomp your heels Qi and blood flow downwards   After opening up the middle burner pathway through imagining wings, swinging arms, and revitalizing the mind, it is necessary to drain the qi and blood from the upper burner.   Action essentials: Stand up straight, take steps in place, lift your legs, and stomp your heels when landing. Guide the flow of qi and blood downwards.   Benefits: Reduce internal environmental pressure, prevent qi and blood from attacking the heart and brain, relieve unsteady footsteps and rootless feet.   Stomping feet and schematic diagram       8. Energy sinking   In the era of the Internet, there are many brain teasers Blood surges upwards but struggles to descend Energy sinks, qi and blood move Yunhua cycle can promote health and wellness   By combining imagination with physical massage, it is possible to guide qi and blood to flow down to the feet, restoring the balance of the body's qi and blood circulation   Action essentials: The first step is to imagine a lotus flower under your feet. It can be with both feet on a lotus flower, or with a lotus flower at each foot. Lotus flowers can be red, white, or any other color, and the size can be determined by oneself. Lotus is a perennial aquatic plant with the characteristic of water. By imagining lotus flowers, one can help reduce fire, purify, expel pathogenic qi, and facilitate the sinking of qi and blood.   We can go to the park to observe lotus flowers, search for some pictures of lotus flowers online, and then imagine them. You can also use household items such as socks, slippers, and floor mats with lotus patterns to help better imagine.   When imagining, one should relax. Lotus flowers can be imagined in a very specific way or in a more vague way. If the lotus flower you come up with is not clear, don't worry. Just go to the point where you can think of it. The key is to maintain attention and keep the lotus flower on your feet.   Energy sinking health preservation method   Step two, massage the head. While imagining the lotus flower under your feet, hold your head with both hands and massage and push downwards symmetrically from the top to the center. When massaging, apply appropriate force to ensure that your hands are symmetrical. Massage can be divided into eight directions and four pairs, including left and right, front and back, left front and right back, right front and left back, etc. The massage range covers the head.   Before the massage, headwear, rubber bands, glasses, and other items can be removed for easy palm pushing. The massage intensity, duration, and frequency should be based on comfort. If discomfort or discomfort occurs, stop immediately.     Massage the head with both hands   In addition, imagining the lotus flower under your feet (Step 1) can also be used independently, allowing you to imagine anytime, anywhere in any situation such as studying, working, thinking, walking, queuing, dancing, resting, etc. You can focus on imagination, or keep imagining after imagining the lotus flower, and then do other things. If you interrupt your imagination because you want something else, don't worry, just imagine again.   Application of Energy Sinking Health Preservation Method   Special reminder: People with low blood pressure, hypoglycemia, anemia and other conditions can use less or no energy sinking as appropriate. In addition, pregnant women should also use it sparingly. If you feel uncomfortable or uncomfortable during the process, you should stop immediately.   Benefits: Attract qi to descend, ignite fire to return to its original state, lower blood pressure and reduce fire, relieve dryness and dryness in the eyes, relieve stress, balance emotions, refresh the mind, relieve irritability and heat, improve cold hands and feet, balance physical and mental functions, and also improve symptoms such as nausea, vomiting, and headache.   9. The method of generating fluids for health preservation   Rotate clockwise around the base of the tongue to produce saliva The fire ignites, the wind borrows the fire, and the spiral turns upwards Activate hydraulic power, continuous circulation, widely distributed throughout the day Water and liquid converge, springs flow continuously, and sweet dew fills the air Moisturize and nourish, nourish the blood vessels, and make the skin radiant and green   Under the tongue is the main valve for human body fluids. After the rebalancing of qi and blood, it is necessary to promote the comprehensive circulation of water throughout the body, so that all organs and cells in the body can be nourished.   Action essentials: Close your mouth, place your tongue against your gums (both inside and outside), and gently massage your gums in a clockwise direction of "up right down left". This will produce sweet saliva in your mouth, which can nourish your body when swallowed.   Benefits: Nourishing saliva and teeth, nourishing blood vessels, long-term use can treat bad breath, nourish the skin, enhance the luster and elasticity of the skin and hair, and effectively improve hair loss problems.   Schematic diagram of the method of generating fluids for health preservation   10. Stepping with sharp toes (closing posture) Spinal connectivity throughout the entire body Hands in the sky, feet in the ground Qi and blood are interconnected from top to bottom Yunhua Cycle Warm Runyu   Action essentials: Stand naturally with feet parallel and shoulder width apart. Fold your hands together in front of you, slowly raise and straighten your arms, stretch them up to the highest point, and then stand on tiptoe, as if hanging your whole body with a rope. Imagine your hands stretching infinitely upwards and infinitely deep, and your feet stretching infinitely downwards and infinitely deep. Hold your body in an extended position for 5 seconds, then slowly lower your hands synchronously, and your hands naturally hang down to your sides. This is one movement. Repeat this action and pull your body into a straight line. Schematic diagram of tiptoe   Benefits: Straighten the body, promote the circulation of qi and blood, and promote the circulation of the body. Preventing varicose veins, relieving edema, nourishing kidney and qi can have the effect of protecting and improving kidney function.   Summary of Natural Health Exercises: Firstly, the abdominal breathing three open method and respiratory smelting method are used to vigorously activate the whole body's qi and blood. In addition, the method of promoting digestion, nutrient absorption, and waste excretion is used to regulate and ensure the normal function of the lower burner; Then, by imagining wings, swinging arms, and feeling refreshed, three different levels of upper limb movements are used to clear the middle focus and open up the pathway for the rise and fall of qi and blood; Then, by stomping the heels and using the energy sinking health preservation method, the qi and blood are drawn down from above to achieve a rebalancing of the body's qi and blood. The body's water circulation is regulated through the nourishing method of generating fluids; Finally, by tiptoeing, straighten and straighten the areas where the body may be misaligned, from head to spine, and from the three burners to the five organs, ensuring comprehensive systemic circulation in the human body. Through ten exercises, restore the original functions of various organs and play their due roles. Regular practice of natural health exercises can restore the body's natural rhythm, improve physical fitness, and prevent the occurrence of various diseases. When doing exercises, one should be correct, natural, sufficient, in place, and self consistent, avoiding going too far.         Source: https://www.thinkflow.com.cn/ ​

History, efficacy and function of Chenodeoxycholic acid

Chenodeoxycholic acid was isolated in 1924 from goose gall by Adolf Windaus and human gall by Heinrich Wieland.Its complete structural configuation was elucidated by Hans Lettre at the University of Gottingen.   In 1968, William Admirand and Donald Small at Boston University Medical School established that in patients with gallstones their bile was saturated with cholesterol, sometimes even exhibiting microcrystals, whereas this was not the case in normal people.It was then found that biliary levels of cholic acid and chenodeoxycholic acid were lower in patients with cholesterol gallstones than in normal people. Leslie Thistle and John Schoenfield at the Mayo Clinic in Rochester, Minnesota, then administered individual bile salts by mouth for four months and found that chenodeoxycholic acid reduced the amount of cholesterol in the bile.This led to a national collaborative study in the United States, which confirmed the effectiveness of chenodeoxycholic acid in bringing about dissolution of gallstones in selected patients. However, recent developments such as laparoscopic cholecystectomy and endoscopic biliary techniques have curtailed the role of chenodeoxycholic acid and ursodeoxycholic acid in the treatment of cholelithiasis.     Chenodeoxycholic acid is a bile acid synthesized in the liver from cholesterol. henodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX). It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies. Chenodeoxycholic acid is the first agent to be introduced into the US market for the treatment of radiolucent gallstones. Large scale clinical trials have demonstrated the safety and efficacy of this agent.     Chenodeoxycholic acid reduces the biliary concentration of cholesterol relative to that of bile acids and phospholipid, reducing the saturation and thus the lithogenicity of the bile. Success rates in dissolving gallstones are in the range of 50-70% within 4-24 months of treatment. Continuation of the drug after stone dissolution may be required to prevent reoccurrence. Chenodeoxycholic acid is the 7α-isomer of ursodeoxycholic acid which was introduced into the European market in 1978.     Chenodeoxycholic acid is a bile acid that induces apoptosis through protein kinase C signaling pathways.It is a major bile acid in many vertebrates, occurring as the N-glycine and/or N-taurine conjugate. With other bile acids, forms mixed micelles with lecithin in bile which solubilize cholesterol and thus facilitates its excretion.Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress. Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.     Chenodeoxycholic acid is widely utilized in therapeutic applications. It is applied in medical therapy to dissolve gallstones. It is employed in the treatment of cerebrotendineous xanthomatosis. It is used to treat constipation and cerebrotendineous xanthomatosis. It acts as a urea receptor in supramolecular chemistry which can contain anions. It is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for dye solar cells.   Chenodeoxycholic Acid is a staining additive commonly used with ruthenium or organic photo-sensitizers in the preparation of staining solutions for Dye Solar Cells. This co-adsorbent will prevent dye aggregation on the semiconductor surface, reducing losses in the solar cell's operation.   Chenodeoxycholic Acid is a white solid added with the dye powder to the solvent while preparing staining solutions. The concentration of co-adsorbent is typically 10 fold the dye concentration.   Chenodeoxycholic acid has been used in a study to assess its effects as a long-term replacement therapy for cerebrotendinous xanthomatosis (CTX).   It has also been used in a study to investigate its effects on the small-intestinal absorption of bile acids in patients with ileostomies. Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid that activates nuclear receptors involved in cholesterol metabolism.EC50 concentrations for activation of FXR range from 13-34 μM.In cells, CDCA also binds to bile acid binding proteins (BABP) with a reported stoichiometry of 1:2.CDCA toxicity is linked to increased cellular glutathione levels and increased oxidative stress. Exposure of cells to excess CDCA contributes to liver and intestinal cancers.  

The efficacy and production methods of UDCA

Bile promoting drugs can generally be divided into two types: bile promoting agents and liquid enhancing bile promoting agents. The former refers to drugs that can promote bile secretion, while the latter refers to drugs that only increase bile volume but do not increase bile components. The commonly used cholestatic drugs are mainly bile acids. There are sodium cholic acid, dehydrocholic acid, chenodeoxycholic acid, and ursodeoxycholic acid.   Ursodeoxycholic acid is a chemical preparation that separates natural bile acids from bear bile. It is a stereoisomer of chenodeoxycholic acid, and its litholytic effect and therapeutic effect are similar to those of chenodeoxycholic acid, but the treatment course is short and the dosage is small. It combines with taurine in the body and exists in bile as a hydrophilic bile acid, serving as a cholesterol stone solubilizer. It can reduce the secretion of cholesterol by the liver, lower the saturation of cholesterol in bile, promote the secretion of bile acids, increase the solubility of cholesterol in bile, dissolve cholesterol stones, or prevent the formation of stones. It can increase the secretion of bile, relax the sphincter of the bile duct, and have a diuretic effect, which is conducive to the discharge of stones. This product cannot dissolve other types of gallstones. Ursodeoxycholic acid is suitable for treating cholesterol stones, hyperlipidemia, bile secretion disorders, primary biliary cirrhosis, chronic hepatitis, bile reflux gastritis, and preventing acute rejection and reactions of liver transplantation. The stone dissolving effect of this product is slightly weaker than that of chenodeoxycholic acid.     Production method Method 1: Use chenodeoxycholic acid as raw materials Preparation of 3α, 7α-diacetyl cholic acid methyl ester; Take 36ml of anhydrous methanol, and pass through 1g dried hydrogen chloride gas, add bile acid 12g, stir, heat and reflux for 20-30min. After standing for several hours at room temperature when crystals are separated out, freeze, filter, wash with ether, and dry to obtain methyl cholate. Take 2g methyl cholate, add 9.6 mL of benzene, 2.4mL pyridine, 2.4 mL of acetic anhydride, shake for 10-15min, stand for 20h at room temperature, then pour the reaction mixture into 100ml of water, remove the benzene layer, repeatedly wash with distilled water before recycling the solvents. Wash the solid residue with petroleum ether once, and re-crystallize with methanol-aqueous solution to obtain 3α, 7α-diacetyl bile acid methyl ester. Bile acid methyl → → 3α, 7α-diacetyl bile acid methyl ester Preparation of Chenodeoxycholic acid: Take the 1.5 g diacetyl bile acid methyl ester, add 24 mL acetic acid, add potassium chromate solution (Take 0.76g potassium chromate to dissolve it in 1.8ml take in water), heated to 40 °C, perform reaction for 8h, add water 120ml, shaking for some moment, placed 12h, filter, wash with distilled water till neutralization, dry to give 3α, 7α-diacetoxy-12-keto bile acid methyl ester, referred briefly as the 12-ketone. Take 12-15 g 12-ketone, add 150 mL 2-glycol ether, 15 mL 80% hydrazine hydrate solution, and 15 g potassium hydroxide. Heat to 30 °C and reflux for 15h, heat to 195-200 °C, refluxed for 2.5h, heat to 217 °C for some moment of reaction cool to 190 °C, add 0.7ml hydrazine hydrate solution, heat from within 215 °C to 220 °C within 3h, cool, add 600mL distilled water, adjust to pH 3 with 10% sulfuric acid, separate out the crystals, filter, wash with water until neutralization. Add ethyl acetate, dump the aqueous layer, use water to wash the organic layer was washed for 1-2 times, vacuum distillation and obtain 3α, 7α-dihydroxy cholanic acid, namely Chenodeoxycholic acid. 3α, 7α-diacetyl methyl cholate → 3α, 7α-diacetoxy-12-Keto ursodeoxycholic acid methyl ester → 3α, 7α-dihydroxy ursodeoxycholic acid (Chenodeoxycholic acid) Preparation of refined ursodeoxycholic acid; Taken 2 g chenodeoxycholic acid, add 100ml of acetic acid and 20g potassium acetate, shake to dissolve. Add potassium chromate 1.5g (dissolved in 10 mL of water), at room temperature overnight, add water 200ml, separate out the crystals, filter, wash, and dry to obtain 3α-hydroxy-7-keto-ursodeoxycholic acid. Take 4g 3α-hydroxy-7-keto-ursodeoxycholic acid, add 100 mL n-butanol, heat to about 115 °C, gradually add 8 g metal sodium after which, white slurry gradually comes out, keep reaction for 30min, add 120ml water, stir and heat to transparently dissolve. Evaporate the organic layer under reduced pressure; add 500 mL water to the residue, dissolve, and filter. Adjust the pH the filtrate to pH 3 with 10% sulfuric acid which will yield white precipitate, filter, wash till neutralization with water, dry, wash with ethyl acetate, crystallize with diluted ethanol and obtain 3α, 7β-dihydroxycholanic acid, that’s refined ursodeoxycholic acid. Chenodeoxycholic acid [potassium chromate] → 3α-hydroxy-7-keto acid [sodium metal, 115 °C] → 3α, 7β-Keto ursodeoxycholic acid methyl ester (Ursodeoxycholic acid) Method 2: Use pig bile or bile salts as raw material; Use thin layer chromatography to isolate ursodeoxycholic acid from pigs bile or bile salt. Pig bile salt contains free and bound type of UDCA whose content is about 30%; pig bile contains bound UDCA whose content is about 0.6%.

Synthesis route of new hypoglycemic drug sitagliptin phosphate

Sitagliptin phosphate, developed by MSD, was approved by the US FDA for listing in October 2006. It is the first dipeptidyl peptidase IV (DPP-4) inhibitor used to treat type 2 diabetes. The effect of cetagliptin phosphate on type 2 diabetes is very ideal. As a new anti diabetes drug, cetagliptin phosphate is glucose dependent and has moderate hypoglycemic effect. It can increase insulin secretion without hypoglycemia, effectively reduce hunger and other advantages, and has no side effects such as nausea, vomiting, edema and increasing body mass.     Sitagliptin phosphate can enhance the body's ability to reduce excessive blood sugar levels by inhibiting the activity of this enzyme, which relatively increases the levels of naturally occurring intestinal proinsulin, including glucagon like peptide-1 and glucose dependent proinsulin peptide. This triggers the pancreas to increase insulin production and stops glucose production in the liver, ultimately reducing blood sugar concentration. This product is characterized by stimulating insulin secretion, reducing hunger, not increasing weight, nor hypoglycemia and edema. It is suitable for diabetes patients with poor blood sugar control and frequent hypoglycemia.   According to the clinical verification of 552 patients with mild to moderate type 2 diabetes, taking cetagliptin phosphate once a day and 100mg each time can reduce the glycosylated hemoglobin by 0.6% -1.1% after 12 weeks. The incidence of adverse reactions is similar to that of placebo, with the most commonly reported adverse reactions (incidence>5% and higher than placebo) being nasal congestion or runny nose, as well as sore throat, upper respiratory tract infection, and headache. Clinical studies have shown that cetagliptin phosphate, as a single drug, can significantly reduce the level of glycosylated hemoglobin (HbA1c) in patients with type 2 diabetes. When used in combination with metformin or TZDs, it has significant adjunctive therapeutic effect and can target three major defects of type 2 diabetes: insulin resistance, β Cellular dysfunction (reduced insulin release), and α Cellular dysfunction (without inhibiting liver glucose production) plays a role. But it is not suitable for the treatment of type 1 diabetes patients or diabetes ketoacidosis.     Sitagliptin phosphate is used to treat type 2 diabetes. After taking it, many patients can promote the secretion of insulin in the body, control blood sugar, and prevent the recurrence of diabetes. Some patients, after taking it, can promote the speed of cellular and blood metabolism throughout the body, eliminate accumulated toxins and waste, and also improve the sub health symptoms that appear in the body. For consumers who are allergic to this medication during use, it is not advisable to take it as it may cause symptoms such as nausea, vomiting, and dizziness. In severe cases, it can also lead to poisoning and shock. Therefore, it is recommended that consumers carefully read the instructions before taking it, and regularly go to the hospital for examination to pay attention to their physical health.     There are many synthetic routes for sitagliptin, among which the commonly used route is based on 2,4,5-Trifluorophenylacetate acid as the starting material.   Our company can supply the following intermediates. Please feel free to purchase and inquire. Sitagliptin phosphate monohydrate CAS 654671-77-9 2,4,5-Trifluorophenyl acetic acid CAS 209995-38-0 Meldrum acid CAS 2033-24-1 3-(Trifluoromethyl)-5,6,7,8,-tetrahydro[1,2,4]triazolo[4,3-a]pyrazine HCl CAS 762240-92-6  
1