2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole CAS 106006-83-1

Product Description:

Product Name: 2,6-Diamino-4,5,6,7-tetrahydrobenzothiazole CAS NO:106006-83-1

Synonyms:

2,6-Diamino-4,5,6,7-Tetra-Hydrobenzothiazol;

4,5,6,7-tetrahydrothieno[3,4-c]pyridine-1,3-diamine;

Chemical & Physical Properties:

Appearance : White powder.

Assay : ≥99.0%

Density: 1.31g/cm3

Melting point: ＞180℃

Boiling Point: 359℃ at 760 mmHg

Flash Point: 170.9±27.9℃

Refractive Index: 1.476

Vapor Pressure: 0.0±0.8 mmHg at 25℃

PSA: 93.17000

LogP: 1.82280

Solubility: Methanol (Slightly).

Category: Standards; Pharmaceutical/API Drug Impurities/Metabolites;

Safety Information:

HS Code: 2934999090

Safety Statements: S26-S36/37/39

WGK Germany :3

Risk Statements: R36/37/38

Hazard Codes: Xi

Storage:Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Application:

2,6-Benzothiazolediamine,4,5,6,7-tetrahydro is used to make the Parkinson's drug Pramipexole; Pramipexole intermediate;

Pramipexole is a dopamine receptor agonist that binds to the D2 subfamily of dopamine receptors with high selectivity and specificity, and has complete intrinsic activity. It has a preferential affinity for the D3 receptor among them.

Pramipexole relieves movement disorders in patients with Parkinson's by exciting dopamine receptors in the striatum.

Pramipexole is quickly and completely absorbed orally. The absolute bioavailability is higher than 90%. The maximum plasma concentration appears between 1-3 hours after taking the drug. Taking it with food will not reduce the degree of pramipexole absorption, but it will reduce its absorption rate. Pramipexole shows linear kinetic characteristics, with little difference in plasma levels between patients. Pramipexole has very low plasma protein binding (less than 20%) and a large volume of distribution (400L).

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Inventory Status : In Stock.

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