N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-QuinazolinAmine CAS 314771-88-5

Product Description:

Product Name: N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-QuinazolinAmine CAS NO:314771-88-5

Synonyms:

4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-;

(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine;

N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[(3S)-tetrahydro-3-furanyloxy]-4-quinazolinamine;

N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[[(3S)-tetrahydro-3-furanyl]oxy]-4-quinazolinamine;

(S)-N-(3-Chloro-4-fluorophenyl)-6-nitro-7-[(tetrahydrofuran-3-yl)oxy]quinazolin-4-amine;

4-[(3-Chloro-4-fluorophenyl)amino]-6-nitro-7-((5)-tetrahydrofuran-3-yloxy)-quinazoline;

(2Z)-Afatinib intermediate;

Chemical & Physical Properties:

Appearance :Yellow powder.

Assay : ≥99.0%, EE ≥99.5%

Density: 1.5 g/cm3

Boiling Point:585℃ at 760 mmHg

Flash Point:307.6℃

(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.