Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 441798-33-0
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
441798-33-0 |
Appearance :: |
White Powder |
Molecular Formula:: |
C19H22Br2N6O4S |
Molecular Weight:: |
590.28 |
EINECS NO:: |
1308068-626-2 |
MDL NO:: |
MFCD17167076 |
CAS NO:: |
441798-33-0 |
Appearance :: |
White Powder |
Molecular Formula:: |
C19H22Br2N6O4S |
Molecular Weight:: |
590.28 |
EINECS NO:: |
1308068-626-2 |
MDL NO:: |
MFCD17167076 |
Product Description:
Product Name: Macitentan CAS NO: 441798-33-0
Synonyms:
5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(propylsulfamoyl)pyrimidin-4-amine;
N-[5-(4-Bromophenyl)-6-{2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy}-4-pyrimidinyl]-N'-propylsulfuric diamide;
Sulfamide,N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propyl-;
Macitentan;
Actelion-1;
Opsumit;
Chemical & Physical Properties:
Appearance : White powder
Assay :≥99.0%
Density:1.675g/cm3
Boiling point:692.4°Cat 760 mmHg
Flash Point:372.5℃
Macitentan (trade name Opsumit) is an endothelin receptor antagonist (ERA) approved for the treatment of pulmonary arterial hypertension (PAH). The other two ERAs marketed as of 2014 are bosentan and ambrisentan. Macitentan is a dual ERA, meaning that it acts as an antagonist of two endothelin (ET) receptor subtypes, ETA and ETB. However, macitentan has a 50-fold increased selectivity for the ETA subtype compared to the ETB subtype. The drug received approval from the U.S. Food and Drug Administration (FDA) on October 13, 2013.
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