4-Chloro-3-(trifluoromethyl)phenyl Isocyanate CAS 327-78-6

Product Description:

Product Name: 4-Chloro-3-(trifluoromethyl)phenyl isocyanate CAS NO: 327-78-6

Synonyms:

Sorafenib intermediate 3;

Isocyanic Acid 4-Chloro-3-(trifluoromethyl)phenyl Ester;

1-chloro-4-isocyanato-2-trifluoromethylbenzene;

Chemical & Physical Properties:

Appearance: Off-white crystal

Assay :≥98.0%

Density: 1.4 g/cm3

Boiling Point: 86-90℃ (14 mmHg)

Melting Point: 35-36℃

Flash Point: 99℃

Refractive Index: 1.487

Safety Information:

Packing Group: III

WGK Germany: 3

RIDADR: UN 2206

Risk Statements: R20/21/22; R36/37/38

Signal Word: Warning

Safety Statements: S26-S36/37/39

HS Code: 2929109000

Hazard Codes: Xn

Hazard Class: 6.1

Hazard Statements: H302-H312-H315-H319-H332-H335

Precautionary Statements: P261-P280-P305 + P351 + P338

4-Chloro-3-(trifluoromethyl)phenyl isocyanate is used as a reagent to synthesize pyrimidinylaminobenzene derivatives, compounds that have antiproliferative activity against melanoma cell lines. 4-Chloro-3-(trifluoromethyl)phenyl isocyanate is also used to synthesize α-thymidine analogues that act as antimalarial agents. 4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of: N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea [1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea] trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.