4-Cyanophenylboronic Acid CAS 126747-14-6

Product Description:

Product Name: 4-Cyanophenylboronic acid CAS NO: 126747-14-6

Synonyms:

4-Cyanobenzeneboronic Acid;

(p-Cyanophenyl)boronic acid 4-Cyanobenzeneboronic acid 4-Cyanophenylboric acid;

(4-cyanophenyl)boronic acid;

Chemical & Physical Properties:

Appearance: White to yellow powder

Assay :≥99.0%

Density: 1.25g/cm3

Boiling Point: 355.9℃ at 760mmHg

Melting Point: >300℃

Flash Point: 169℃

Refractive Index: 1.559

Storage Condition: 0-60℃

Vapor Pressure: 1.11E-05mmHg at 25℃

Safety Information:

Symbol (GHS) : GHS06,GHS07

Signal Word: Danger

Safety Statements: S26-S37/39

Hazard Code: Xi

Hazard Class: 6.1

HS Code: 2931900090

Packing Group: III

WGK Germany: 3

RIDADR: UN3439

Risk Statements: R36/37/38

Hazard Statements: H301+H311+H331-H315-H319-H301-H335

Precautionary Statements:

P280a-P301+P310a-P305+P351+P338-P501a-P261-P264-P270-P271-P280-P301+P310+P330-P302+P352+P312+P361+P364-P304+P340+P311-P305+P351+P338+P337+P313-P403+P233-P405-P501

4-Cyanophenylboronic Acid is a reactant used in the synthesis of (AMG-8718), an inhibitor of β-site amyloid precursor protein cleaving enzyme (BACE1). 4-Cyanophenylboronic acid can be used for palladium catalyzed Suzuki cross-coupling reactions to synthesize 6-acryl-2,4-diamino-pyrimidines and triazines. It is used as precursor in the synthesis of inhibitors such as Tpl2 kinase inhibitors and P2X7 antagonists used in the treatment of pain. It is also a reagent used for preparation of himbacine analogs as thrombin receptor antagonists and potential antiplatelet agents, trisulfonated calixarene upper-rim sulfonamido and their complexation with trimethyllysine epigenetic mark, antimalarial compounds via Suzuki cross-coupling, and deoxyuridine derivatives.

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