![Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(3-methylphenyl)- CAS 125079-83-6](/images/load_icon.gif){kind=icon}
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Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 125079-83-6
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
125079-83-6 |
Appearance:: |
Crystalline Solid |
Molecular Formula:: |
C14H12N4O |
Molecular Weight:: |
252.27 |
EINECS NO:: |
NA |
MDL NO:: |
MFCD31692371 |
CAS NO:: |
125079-83-6 |
Appearance:: |
Crystalline Solid |
Molecular Formula:: |
C14H12N4O |
Molecular Weight:: |
252.27 |
EINECS NO:: |
NA |
MDL NO:: |
MFCD31692371 |
Product Description:
Product Name: Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 7-(3-methylphenyl)- CAS NO: 125079-83-6
Synonyms:
CU-CPT-8M;
TLR8 INHIBITOR;
CPD1578;
Chemical & Physical Properties:
Appearance: Crystalline solid
Assay :≥98.0%
Density: 1.35±0.1 g/cm3 (Predicted)
PKa: 12.41±0.50 (Predicted)
Solubility: DMSO ≥ 22 mg/mL
Storage: at -20℃
CU-CPT-8m is a specific TLR8 antagonist, with an IC50 of 67 nM. CU-CPT8m is an antagonist of toll-like receptor 8 (TLR8) with Kd of 220 nM and IC50 of 67 nM in assay. Treatment of 1 μM CU-CPT-8m completely abolishes the elevation of TNF-α and IL-8 mRNA levels induced by R848. CU-CPT-8m inhibits R848-induced TNF-α production in the differentiated THP-1 monocytes cells in a dose-dependent manner with an IC50 of 90±10 nM, which is in good agreement with its IC50 value determined in HEK-Blue TLR8 cells.
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