3α-hydroxy-5α-pregnan-20-one CAS 516-54-1

Product Description:

Product Name: 3α-hydroxy-5α-pregnan-20-one CAS NO: 516-54-1

Synonyms:

(3α)-Allopregnanolone;

Pregnan-20-one, 3-hydroxy-, (3α,5α)-;

3alpha-hydroxy-5alpha-pregnan-20-one;

Chemical & Physical Properties:

Appearance: White solid

Assay :≥98.0%

Density: 1.053g/cm3

Boiling Point: 431.2℃ at 760mmHg

Flash Point: 183.9℃

Refractive Index: 1.524

Storage Condition: Store at RT

Vapor Pressure: 0.0±2.3 mmHg at 25℃

Water Solubility: chloroform: 20 mg/mL, clear, colorless

Safety Information:

Safety Statements: S22; S24/25

WGK Germany: 3

RTECS: TU4383000

F: 10

Allopregnanolone (ALLO), also known as 3α-hydroxy-5α-pregnan-20-one or 3α,5α-tetrahydroprogesterone (3α,5α-THP), is an endogenous inhibitory pregnane neurosteroid. It is synthesized from progesterone, and is a potent positive allosteric modulator of the action of gamma-amininobutyric acid (GABA) at GABAA receptor. Allopregnanolone has effects similar to those of other positive allosteric modulators of the GABA action at GABAA receptor such as the benzodiaze-pines, including anxiolytic, sedative, and anticonvulsant activity.

Endogenously produced allopregnanolone exerts a pivotal neurophysiological role by fine-tuning of GABAA receptor and modulating the action of several positive allosteric modulators and agonists at GABAA receptor. The 21-hydroxylated derivative of this compound, tetrahydrodeoxycorticosterone (THDOC), is an endogenous inhibitory neurosteroid with similar properties to those of allopregnanolone, and the 3β-methyl analogue of allopregnanolone, ganaxolone, is under development to treat epilepsy and other conditions, including post-traumatic stress disorder (PTSD).

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