Benzoicacid, 4-amino-2-fluoro- CAS 446-31-1

Product Description:

Product Name: Benzoicacid, 4-amino-2-fluoro- CAS NO: 446-31-1

Synonyms:

2-FLUORO-4-AMINOBENZOIC ACID;

4-AMINO-2-FLUOROBENZOIC ACID;

BUTTPARK 22�9-96;

Chemical & Physical Properties:

Appearance: White to tan grey powder, crystals or crystalline powder or chunks

Assay :≥99.0%

Density: 1.43 g/cm3

Boiling Point: 336.1℃ at 760 mmHg

Melting Point: 210℃

Flash Point: 157℃

Refractive Index: 1.606

Vapor Pressure: 0.000155mmHg at 25℃

Safety Information:

Safety Statements: S26-S36

HS Code: 2922499990

WGK Germany: 3

Risk Statements: R22; R37/38; R41

Hazard Codes: Xi; Xn

Hazard Declaration: H302; H315; H318; H335

Symbols: GHS05, GHS07

Caution Statements: P261; P280; P305 + P351 + P338

Signal Word: Danger

4- amino-2 - fluorobenzoic acid is an important intermediate of many drugs, which is widely used in organic synthesis and pharmaceutical industry. At present, the main preparation methods of 4-amino-2-fluorobenzoic acid are WO2001042198, WO2004011460, WO2007138033, WO2010034796, WO2010132615. The reported use of 2-fluoro-4-nitrobenzoic acid as raw materials, After Pd/C hydrogenation and Chemicalbook original preparation, and its raw material 2-fluoro-4-nitrobenzoic acid is often prepared by 2-fluoro-4-nitrotoluene and strong oxidation of potassium permanganate or potassium dichromate; In addition, WO2008118758 and WO2010035166 reported that 2-fluoro-4-aminobenzonitrile was prepared by alkaline hydrolysis as raw material.

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