2-Bromo-5-chloropyridine CAS 40473-01-6

Product Description:

Product Name: 2-Bromo-5-chloropyridine CAS NO: 40473-01-6

Synonyms:

5-chloro-2-bromopyridine;

2-BroMoo-5-chloropyridine;

Chemical & Physical Properties:

Appearance: Light brown to yellow crystalline powder

Assay :≥98.0%

Density: 1.736 g/cm3

Boiling Point: 212℃ at 760 mmHg

Melting Point: 65-69℃

Flash Point: 82℃

Refractive Index: 1.581

Water Solubility: Slightly soluble in water

Safety Information:

Safety Statements: S22-S26-S36/37/39

HS Code: 2933399090

RIDADR: Cool, dry,tightly closed

Risk Statements: R20/22; R36/37/38

Hazard Codes: Xn,Xi

2-bromo-5-chloropyridine is an organic intermediate, a colorless solid, which can be prepared from 2-amino-5-chloropyridine by diazotization reaction or 2, 5-dichloropyridine by hydrogen bromide substitution. Bromine (18.0 mL, 353.7mmol) was slowly added to a solution of 2-amino-5-chloropyridine (15.0g, 116.7mmol) in 47% aq. hBr (75.0 mL) at -10℃. An aqueous solution of NaNO2(28.1g, 4chemicalbook073.3mmol) was slowly added to it. The mixture was stirred at -10 to -5 ° C for 1h and then at 5 ° C for 1h. The mixture was neutralized with 5MNaOH aqueous solution when the temperature was maintained below 25℃. The precipitates were filtered out and recrystallized with pentane to obtain 2-bromo-5-chloropyridine.

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