3,5-dibromopyridine CAS 625-92-3

Product Description:

Product Name:3,5-dibromopyridine CAS 625-92-3

Synonyms:

3,5-dibromo-pyridine;

Chemical & Physical Properties

Appearance:Yellowish0.52±0.20 solid

Assay: 99%+

Boiling point:222℃

Melting point:110-115℃

Flash point:84.3℃

Pka:.52±0.20

Refractive index:1.5800

Density:1.1256g/cm³

Application

3, 5-dibromopyridine is a white to light yellow crystalline powder that can be used as a pharmaceutical intermediate.

3-Acetylamino-5-ethoxypyridine was prepared by converting 3, 5-dibromopyridine with sodium ethylate into 3-bromo-5-ethoxypyridine, allowing this substance to interact with ammonia and acetylating the aminoethoxypyridine thus formed with acetic anhydride. Lithiation of 3, 5-dibromopyridine with LDA and subsequent reaction with electrophiles provided 4-alkyl-3, 5-dibromopyridines 2 in high yield. Ligand was prepared by a Pd(0)-catalyzed cross-coupling reaction of 3,5-dibromopyridine and 5-tributylstannyl-3,3?-bipyridine. The synthesis of 3, 5-bis (2-indolyl) pyridine and 3-[(2-indolyl)-5-phenyl] pyridine derivatives as includes Stille or Suzuki type reactions, which were realized on the 3,5-dibromopyridine.

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