Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 2169271-28-5
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Packaging Details: Aluminum Foil Bag, Drum/Plastic bottles, Plastic buckets
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS No:: |
2169271-28-5 |
Appearance:: |
N/A |
Molecular Formula:: |
C16H13FN2O3S |
Molecular Weight:: |
332.35 |
EINECS NO:: |
N/A |
MDL NO.:: |
N/A |
CAS No:: |
2169271-28-5 |
Appearance:: |
N/A |
Molecular Formula:: |
C16H13FN2O3S |
Molecular Weight:: |
332.35 |
EINECS NO:: |
N/A |
MDL NO.:: |
N/A |
Product Description:
Product Name:(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol CAS 2169271-28-5
Synonyms:
TAK438 Impurity 1;
Vonoprazan impurity 37;
1-[(2-chloro-3-pyridinyl)sulfonyl]-5-(2-fluorophenyl)-1H-Pyrrole-3-carboxaldehyde；
Chemical & Physical Properties
Appearance:N/A
Assay: 99%+
Boiling point:564.5±60.0℃
Density:1.38±0.1g/cm3
Pka:13.89±0.10
Application
(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl) methanol is an intermediate of Vonorazan.Vonorazan fumarate (TAK-438), a potassium ion (K+) competitive acid blocker (P-CAB), is a reversible proton pump inhibitor. After entering the human body, the product terminates the secretion of gastric acid by inhibiting the binding of K+ and H+-K+ -ATPase (proton pump) in the last step of acid secretion in gastric parietal cells. This product has a strong and lasting inhibitory effect on gastric acid secretion.
Compared with the traditional proton pump inhibitor lansoprazole, Vonoprazan works by competitive and reversible inhibition of K+ in the proton pump. Clinical and animal experiments have shown that Vonoprazan acts faster than PPI or H2 blockers, has a stronger effect on increasing pH, can rapidly relieve gastrointestinal symptoms, and restore enzyme activity after digestion. Less adverse reactions,Vonorazan has high lipophilicity and high dissociation constant, and can be effective in acidic environments without acid activation. Vonorazan inhibits the proton pump without acid activation and enters the stomach in high concentrations, producing the greatest inhibitory effect on the first dose and lasting for 24 hours. Vonorazan is stable in acid, and can rapidly increase the pH value in the stomach, exerting an acid inhibitory effect.
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