(1R,2S,5S)-methyl 6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylate Hydrochloride CAS 565456-77-1

Product Description:

(1R,2S,5S)-methyl6,6-dimethyl-3-aza-bicyclo[3.1.0]hexane-2-carboxylate hydrochloride CAS 565456-77-1

Synonyms:

Boceprevir InterMediates;

Methyl (1r,2s,5s)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate;

Chemical & Physical Properties

storage temp:Inert atmosphere,Room Temperature

Form:solid

Color:Pale yellow

InChI:InChI=1/C9H15NO2.ClH/c1-9(2)5-4-10-7(6(5)9)8(11)12-3;/h5-7,10H,4H2,1-3H3;1H/t5-,6-,7-;/s3

InChIKey:FKVUDBWXNAFSPB-AUBOPKACNA-N

SMILES:C([C@H]1NC[C@@H]2C(C)(C)[C@H]12)(=O)OC.Cl |&1:1,4,8,r|

Safety Information

HS Code:2933998090

Uses :

The intermediate of Boprevir, namely (1R, 2S, 5S) -6,6-dimethyl-3-azabicyclic [3.1.0] hexane-2-carboxylic acid methyl ester hydrochloride, is the side chain of Boprevir. Pramivir is a hepatitis C protease inhibitor developed by Schering Plough, which can be used as the main drug of triple therapy (with polyethylene glycol α- The combination of interferon and ribavirin is used for the treatment of CHC gene type I chronic hepatitis. The combination of three drugs can cure more than 60% of patients, and polyethylene glycol alone is used α- The cure rate of interferon or ribavirin is 2 to 3 times higher, and boprivir can improve the cure rate while also shortening the treatment time.

Boceprevir (trade name Boceprevir), with the chemical name of (1S, 2S, 5S) - N - (4-amino-1-cyclobutyl-3,4-dioxobutane-2-yl) -3- [(2S) -2- (tert butylamino) -3,3-dimethylbutyryl] -6,6-dimethyl-3-azabicyclo [3.1.0] hexane-2-formamide, is a hepatitis C protease inhibitor developed by American Chemicalbook Schering Plough, It can be used as the main drug for triple therapy (in combination with pegylated interferon and ribavirin) for the treatment of CHC gene type I chronic hepatitis. The combination of three drugs can cure more than 60% of patients, and polyethylene glycol alone is used α– The cure rate of interferon or ribavirin is 2 to 3 times higher, and boprivir can improve the cure rate while also shortening the treatment time. The drug was approved for marketing by the US Food and Drug Administration (FDA) on May 13, 2011. 1R, 2S, 5S) -6,6-dimethyl-3-azabicyclic [3.1.0] hexane-2-carboxylic acid methyl ester hydrochloride (I) is the key intermediate with the highest cost in the side chain synthesis process of Boprevir.

This product is a azabicyclohexane derivative, which can be used to prepare hepatitis C virus (HCV) NS3 serine protease inhibitor. Purpose: The intermediate of Boprevir is an organic synthesis intermediate and a pharmaceutical intermediate, which can be used in laboratory research and development processes and chemical production processes, mainly as a standard and reference substance.

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