BNP-32 (HUMAN) CAS 124584-08-3

Product Description:

Product Name: BNP-32 (HUMAN) CAS NO: 124584-08-3

Synonyms:

Nesiritide,Brain Natriuretic Peptide-32 human,BNP-32;

BNP-32 (human) hydrochloride;

Nesiritide [USAN:INN];

Chemical & Physical Properties:

Appearance: Powder

Assay :≥99.00%

Density: 1.52±0.1 g/cm3(Predicted)

Storage Temp.: −20℃

Water Solubility: Soluble in water at 1mg/ml

Index of Refraction: 1.679

Safety Information:

RTECS: EE1534000

WGK Germany: 3

Nesiritide (Natrecor) is the recombinant form of the 32 amino acid human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. Nesiritide works to facilitate cardiovascular fluid homeostasis through counterregulation of the renin-angiotensin-aldoesterone system, stimulating cyclic guanosine monophosphate, leading to smooth muscle cell relaxation.

Neseritide was believed initially to be beneficial for acute decompensated congestive heart failure. It received approval from the United States' Food and Drug Administration for this purpose in 2001 after initial non-approval. In July 2011 the results of the largest study so far for nesiritide was published in The New England Journal of Medicine; it showed that nesiritide was not associated with a change in mortality or re-hospitalizations.

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