Cemandil Sodium Salt CAS 42540-40-9

Product Description:

Product Name: Cemandil sodium salt CAS NO: 42540-40-9

Synonyms:

Cefamandole formate sodium salt;

CefamandoleNafate;

Cemandil sodium salt;

Chemical & Physical Properties:

Appearance: White solid

Assay :≥99.00%

Melting Point: 190-193℃

Storage Condition: -20℃ Freezer, Under Inert Atmosphere

Safety Information:

Safety Statements: S26; S36

HS Code: 3003201900

Risk Statements: R36/37/38; R42/43

Hazard Code: Xn

WGK Germany: 3

Cefamandole (INN, also known as cephamandole) is a second-generation broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. Cefamandole is no longer available in the United States.

The chemical structure of cefamandole, like that of several other cephalosporins, contains an N-methylthiotetrazole (NMTT or 1-MTT) side chain. As the antibiotic is broken down in the body, it releases free NMTT, which can cause hypoprothrombinemia (likely due to inhibition of the enzyme vitamin K epoxide reductase)(vitamin K supplement is recommended during therapy) and a reaction with ethanol similar to that produced by disulfiram (Antabuse), due to inhibition of aldehyde dehydrogenase.

Cefamandole has a broad spectrum of activity and can be used to treat bacterial infections of the skin, bones and joints, urinary tract, and lower respiratory tract. The following represents cefamandole MIC susceptibility data for a few medically significant microorganisms.

Escherichia coli: 0.12 - 400 μg/ml Haemophilus influenzae: 0.06 - >16 μg/ml Staphylococcus aureus: 0.1 - 12.5 μg/ml; ; CO2 is generated during the normal constitution of cefamandole and ceftazidime, potentially resulting in an explosive-like reaction in syringes.

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