Amphotericin B CAS 1397-89-3

Product Description:

Product Name: Amphotericin B CAS NO: 1397-89-3

Synonyms:

FUNGIZONE;

Halizon;

AMPHOZONE;

Chemical & Physical Properties:

Appearance: Crystalline yellow solid

Assay :≥99.00%

Density: 1.34

Boiling Point: 1140.4℃ at 760 mmHg

Melting Point: >170℃

Flash Point: 643.5℃

Refractive Index: 1.614

Water Solubility: <0.1 g/100 mL at 21℃

Sensitive: Moisture & Light Sensitive

Stability: Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

Storage Condition: 2-8℃

Vapor Pressure: 0mmHg at 25℃

Safety Information:

RTECS: BU2625000

Hazard Class: 6.1(b)

Safety Statements: S26-S36

Packing Group: III

WGK Germany: 3

RIDADR: UN 1759 8

Risk Statements: R36/37/38

Hazard Codes: Xi,C,T,Xn

Amphotericin B is an antifungal drug often used intravenously for serious systemic fungal infections and is the only effective treatment for some fungal infections.

Common side effects include a reaction of fever, shaking chills, headaches and low blood pressure soon after it is infused, as well as kidney and electrolyte problems. Allergic symptoms including anaphylaxis may occur.

It was originally extracted from Streptomyces nodosus, a filamentous bacterium, in 1955, at the Squibb Institute for Medical Research. Its name originates from the chemical's amphoteric properties. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system.

It is of the polyene class. Currently, the drug is available in many forms. Either "conventionally" complexed with sodium deoxycholate (ABD), as a cholesteryl sulfate complex (ABCD), as a lipid complex (ABLC), and as a liposomal formulation (LAMB). The latter formulations have been developed to improve tolerability and decrease toxicity, but may show considerably different pharmacokinetic characteristics compared to conventional amphotericin B.

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