Urapidil Hydrochloride CAS 64887-14-5 Pharmaceutical Intermediates

Product Description:

Product Name: Urapidil hydrochloride CAS NO: 64887-14-5

Synonyms:

6-[3-[4-(2-m-ethoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione,hydrochloride;

Chemical & Physical Properties:

Appearance: White or off-white crystalline powder

Assay :≥99.00%

Boiling Point: 549℃ at 760 mmHg

Melting Point: 156-158℃

Flash Point: 285.8℃

Storage Condition: Desiccate at RT

Safety Information:

RTECS: YQ9862000

Safety Statement: S36

HS Code: 3004909090

WGK Germany: 3

Risk Statement: R22

Hazard Code: Xn

α1-Adrenergic antagonist; derivative of Uracil (U801000). Antihypertensive.Antihypertensive;Serotonergic receptor agonist. Urapidil HCl is an α1-adrenoceptor antagonist and 5-HT1A receptor agonist.Target: α1-adrenoceptor; 5-HT1A receptorUrapidil hydrochloride is a hydrochloride salt form of urapidil which is α1-adrenoceptor antagonist and 5-HT1A receptor agonist with pIC50 of 6.13 and 6.4 respectively. Urapidil has an alpha-blocking effect but, unlike other alpha-blockers, also has a central sympatholytic effect mediated via stimulation of serotonin 5HT1A receptors in the central nervous system .

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