2-(4-FLUOROPHENYL)THIOPHENE CAS 58861-48-6 EINECS NO 611-756-1

Product Description:

Product Name: 2-(4-FLUOROPHENYL)THIOPHENE CAS NO: 58861-48-6

Synonyms:

Thiophene, 2-(4-fluorophenyl)-;

Canagliflozin intermediate;

Canagliflozin INT2;

Chemical & Physical Properties:

Appearance: White solid

Assay :≥99.00%

Density: 1.201g/cm3

Boiling Point: 252.316℃ at 760 mmHg

Flash Point: 106.397℃

Refractive Index: 1.578

Melting Point: 51.0 to 55.0℃

Vapor Pressure: 0.0±0.5 mmHg at 25℃

Safety Information:

HS Code: 2934999090

2-(4-Fluorophenyl)-thiophene can be used to prepare Canagliflozin as sodium-dependent glucose co-transporter 2 (SGLT2) inhibitor for treatment of type 2 diabetes mellitus. 2-(4-fluorophenyl) thiophene is an intermediate for the synthesis of Canagliflozin (Invokana), the first approved sodium glucose cotransporter 2(SGLT2) inhibitor, which was approved by the U.S. Food and Drug Administration in March 2013 for the treatment of type 2 diabetes. Canagliflozin is one of the most effective antidiabetic drugs in recent years. 2-(4- fluorophenyl) thiophene is an important intermediate in the synthesis of this compound. 2-(4-fluorobenzene chemicalbookyl) thiophene is an important intermediate for the synthesis of the antidiabetic drug Canagliflozin, so the crude product 2-(4-fluorophenyl) thiophene needs to be purified. The compound has special physical properties and is white solid at room temperature and liquid at heating. Therefore, it is difficult to separate and purify. The traditional column chromatography separation method is cumbersome and time-consuming, and is not conducive to industrial production. At present, only column chromatography is mentioned in the literature about the synthesis of this compound, but this method is complicated and not easy to be industrialized.

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