Donepezil Hydrochloride CAS 120011-70-3 for Improved Cognitive Function

Product Description:

Product Name: Donepezil Hydrochloride CAS NO: 120011-70-3

Synonyms:

2-(1-Benzyl-4-piperidylmethyl)-5,6-d-imethoxy-1-indanone Hydrochloride;

2,3-Dihydro-5,6-d-imethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride;

2-((1-Benzylpiperidin-4-yl)methyl)-5,6-d-imethoxy-2,3-dihydro-1H-inden-1-one hydrochloride;

Chemical & Physical Properties:

Appearance: White to off-white crystalline solid

Assay :≥99.00%

Boiling Point: 527.9℃ at 760 mmHg

Melting Point: 220-222℃

Flash Point: 273.1℃

Vapor Pressure: 3.11E-11mmHg at 25℃

Safety Information:

Safety Statements: S26-S36

HS Code: 2933399090

RIDADR: UN 2811

Risk Statements: R36/37/38

Hazard Code: Xi

A nootropic. An inhibitor of acetylcholinesterase. Aricept was launched in Canada, Germany, the UK and the US for treatment of mild to moderate Alzheimer’s disease and dementia. It was prepared in three steps beginning with the condensation of 5,6-d-imethoxy-1-indanone with 1-benzylpiperidine- 4-carboxaldehyde. Aricept is a reversible, non-competitive inhibitor of acetylcholinesterase. It is 570-1250 times more selective for acetylcholinesterase than for butylcholinesterase. It has a greater affinity for brain over peripheral acetylcholinesterase with no inhibition in cardiac and smooth muscle, but with slight effects in striated muscle. Aricept inhibited all three isozymes (type A, G2 and G4) of acetylcholinesterase thereby delaying the decline of cholinergics found in the AD brain and slowing the loss of cognitive abilities. It has a 60-70 hr half-life, readily penetrates the CNS, and is 100% bioavailable through the gut with no hepatotoxicity.

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.