Pramoxine Hydrochloride CAS 637-58-1 EINECS NO 211-293-1

Product Description:

Product Name: Pramoxine hydrochloride CAS NO: 637-58-1

Synonyms:

4-[3-(4-butoxyphenoxy)propyl]morpholine,hydrochloride;

Morpholine, 4-[3-(4-butoxyphenoxy)propyl]-, hydrochloride;

Chemical & Physical Properties:

Appearance: White or off white crystalline powder

Assay :≥99.00%

Boiling Point: 427℃ at 760 mmHg

Melting Point: 181-183℃

Flash Point: 123.5℃

Safety Information:

RTECS: QD8750000

Safety Statements: S26-S36

HS Code: 2934999090

Risk Statements: R22; R36/37/38

Hazard Code: Xi

Pramocaine (INN and BAN, also known as pramoxine or pramoxine HCI) is a topical anesthetic discovered at Abbott Laboratories in 1953 and used as an antipruritic. Chemically, it is p-n butoxyphenyl gammamorpholinopropyl e-ther hydrochloride. During research and development, pramoxine hydrochloride stood out among a series of alkoxy aryl alkamine e-thers as an especially good topical local anesthetic agent. Pharmacologic study revealed it to be potent and of low acute and subacute toxicity, well tolerated by most mucous membranes and of a low sensitizing index in humans. Like other local anesthetics, paramoxine decreases the permeability of neuronal membranes to sodium ions, blocking both initiation and conduction of nerve impulses. Depolarization and repolarization of excitable neural membranes is thus inhibited, leading to numbness.

The popular itch creams Gold Bond and some forms of Calamine Lotion use pramocaine hydrochloride to numb sensitive skin, as does the pain relief variant of Neosporin and some formulations of Sarna. The hydrochloride salt form of pramocaine is water-soluble.

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