Tetracaine Hydrochloride CAS 136-47-0 t EINECS NO 205-248-5

Product Description:

Product Name: Tetracaine hydrochloride CAS NO: 136-47-0

Synonyms:

Benzoic acid, 4-(butylamino)-, 2-(d-imethylamino)ethyl ester, monohydrochloride;

4-(Butylamino)benzoic acid 2-(d-imethylamino)ethyl ester,Ameth;

butethanol;

Chemical & Physical Properties:

Appearance: White or off white crystalline powder

Assay :≥99.00%

Boiling Point: 389.4℃ at 760 mmHg

Melting Point: 149℃

Flash Point: 189.3℃

Stability: Stable at normal temperatures and pressures.

Storage Condition: Keep tightly closed.

Vapor Pressure: 2.87E-06mmHg at 25℃

Safety Information:

RTECS: DG4900000

Hazard Class: 6.1

Safety Statements: S26-S36/37-S45

HS Code: 2942000000

Packing Group: III

RIDADR: UN 2811

Risk Statements: R25; R36; R43

Hazard Code: T

Tetracaine (also known as amethocaine) is a local anesthetic of the ester anesthetic group. It is mainly used topically in ophthalmology and as an antipruritic, and it has been used in spinal anesthesia.

In biomedical research, tetracaine is used to alter the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores. Tetracaine is an allosteric blocker of channel function. At low concentrations, tetracaine causes an initial inhibition of spontaneous calcium release events, while at high concentrations, tetracaine blocks release completely.

Tetracaine is the T in TAC, a mixture of 5 to 12 per cent tetracaine, 0.05 per cent adrenaline, and 4 or 10 per cent c-ocaine hydrochloride used in ear, nose & throat surgery and in the emergency department where numbing of the surface is needed rapidly, especially when children have been injured in the eye, ear, or other sensitive locations.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

A systematic review investigated tetracaine for use in emergency departments, especially for IV cannulation in children, in view of its analgesic and cost-saving properties. However, it did not find an improvement in first attempt cannulations.

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