Lapatinib Ditosylate CAS 388082-78-8

Product Description:

Product Name: Lapatinib ditosylate CAS NO: 388082-78-8

Synonyms:

N-(3-Chloro-4-((3-fluorophenyl)m-ethoxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)-2-furanyl)-4-quinazolinamine bis(4-methylbenzenesulfonate) monohydrate;

Lapatinib ditosylate hydrate;

Lapatinib ditosylate Monohydrate;

Chemical & Physical Properties:

Appearance: Colorless to light-yellow crystal

Assay :≥99.00%

Density: 1.403 g/mL (20.84 ℃)

Boiling Point: 750.7℃ at 760 mmHg

Melting Point: 237 – 239℃

Flash Point: 407.8℃

Refractive Index: n20/D 1.5520(lit.)

Safety Information:

Safety Statements: S24; S37; S61

Risk Statements: R43; R51/53

Hazard Codes: Xi; N

Lapatinib (INN), used in the form of lapatinib ditosylate, (USAN) (Tykerb/Tyverb, GSK) is an orally active drug for breast cancer and other solid tumours. It is a dual tyrosine kinase inhibitor which interrupts the HER2/neu and epidermal growth factor receptor (EGFR) pathways. It is used in combination therapy for HER2-positive breast cancer. It is used for the treatment of patients with advanced or metastatic breast cancer whose tumors overexpress HER2 (ErbB2).

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