3-Methylaminop-iperidine Dihydrochloride CAS 127294-77-3

Product Description:

Product Name: 3-Methylaminop-iperidine dihydrochloride CAS NO: 127294-77-3

Synonyms:

N-methylpiperidin-3-amine,dihydrochloride;

3-(Methylamino)p-iperidine dihydrochloride;

Chemical & Physical Properties:

Appearance: White solid

Assay :≥99.00%

Boiling Point: 253.7℃ at 760 mmHg

Melting Point: 199-200℃

Flash Point: 107.2℃

Vapor Pressure: 0.0143mmHg at 25℃

Safety Information:

RTECS: WN2817000

Safety Statements: S26; S36; S37/39

HS Code: 2933399090

WGK Germany: 3

Risk Statements: R22; R36/37/38

Hazard Codes: Xn; Xi

3-m-e-thylamine p-iperidine (1) is an important intermediate for the synthesis of fluoroquinolone antimicrobial balofloxacin. In the literature, 3-m-e-thylamine p-iperidine was obtained from γ-butyllactone through amination, hydrolysis, esterification, condensation with ethyl bromoacetate, cyclization, ester hydrolysis and decarboxylation, reductive amination and hydrodissociation of benzyl. The Chemicalbook grew rapidly and the total yield was low (only 11.5%). 3- methylaminopyridine (4) was prepared from 3- aminopyridine (2) by formylation and reduction with lithium aluminum hydride. Or 2 and triethyl orthoformate were condensed and reduced with sodium borohydride to obtain 4,4 and then reduced by Pd/C to obtain 3-methylamino-p-iperidine diacetate, the total yields were 16% and 32%, respectively.

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