Quetiapine Fumarate CAS 111974-72-2

Product Description:

Product Name: Quetiapine fumarate CAS NO: 111974-72-2

Synonyms:

2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate;

Quetiapine Hemifumarate;

Quetiapine hemifumarate salt;

Chemical & Physical Properties:

Appearance: White crystalline solid

Assay :≥99.00%

Boiling Point: 556.5℃ at 760 mmHg

Melting Point: 174-176℃

Flash Point: 290.4℃

Vapor Pressure: 3.22E-13mmHg at 25℃

Safety Information:

RTECS: PC1075000

Hazard Class: 3

Safety Statements: S53; S45

HS Code: 2934999090

Packing Group: III

WGK Germany: 3

RIDADR: UN 3295 3/PG 3

Risk Statements: R45; R10

Hazard Codes: T; F;N;Xn

Hazard Declaration: H302; H400

Caution Statement: P273

Symbols: GHS07, GHS09

Signal Word: Warning

Used as an antipsychotic. Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties. Quetiapine fumarate is an atypical antipsychotic used in the treatment of schizophrenia, bipolar I mania, bipolar II depression, bipolar I depression.IC50 value: Target: 5-HT ReceptorQuetiapine is indicated for the treatment of schizophrenia as well as for the treatment of acute manic episodes associated with bipolar I disorder. The antipsychotic effect of quetiapine is thought by some to be mediated through antagonist activity at dopamine and serotonin receptors. Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor subtypes are antagonized. Quetiapine also has an antagonistic effect on the histamine H1 receptor.

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