Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1037624-75-1
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
1037624-75-1 |
Appearance:: |
Yellow Powder |
Molecular Formula:: |
C30H34N8 |
Molecular Weight:: |
506.64500 |
EINECS NO:: |
NA |
MDL NO:: |
MFCD28142765 |
CAS NO:: |
1037624-75-1 |
Appearance:: |
Yellow Powder |
Molecular Formula:: |
C30H34N8 |
Molecular Weight:: |
506.64500 |
EINECS NO:: |
NA |
MDL NO:: |
MFCD28142765 |
Product Description:
Product Name: R428 (BGB324) CAS NO: 1037624-75-1
Synonyms:
CS-1046;
R428;
1-(6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-c]pyridazin-3-yl)-N3-(7-(S)-(pyrrolidin-1-yl)-6,7,8,9-tetrahydro-5H-benzo[7]annulene-2-yl)-1H-1,2,4-triazole-3,5-diamine;
Chemical & Physical Properties:
Appearance: Yellow powder
Assay :≥98.0%
Density: 1.41±0.1 g/cm3 (Predicted)
Boiling Point: 799.6±70.0℃(Predicted)
Flash Point: 437.4±35.7℃
PKa: 10.34±0.20 (Predicted)
Vapor Pressure: 0.0±2.8 mmHg at 25℃
Index of Refraction: 1.768
Water Solubility: Insoluble (5.6E-5 g/L) (25℃)
R428(BGB324) is an AXL inhibitor with an IC50 of 14nM and is more than 100 times more selective for AXL than for ABL. The selectivity of action on Axchemicalbookl is also compared to that on MER and Tyro3(50 to 100 times higher) and INSR, EGFR, HER2 and PDGFRβ(more than 100 times higher). Bemcentinib (R428) is a potent and selective inhibitor of Axl with an IC50 of 14 nM.
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