Samuraciclib CAS 1805833-75-3

Product Description:

Product Name: Samuraciclib CAS 1805833-75-3

Synonyms:

(3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl) piperidin-3-ol;

PPDA-001;

ICEC0942 (CT7001) Free base.

Chemical & Physical Properties

Appearance:Solid powder

Assay: NLT98%

Density:1.30 g/cm3

chemical property :Soluble in DMSO

Application:Samuraciclib is a potent, selective, ATP-competitive and orally active CDK7 inhibitor, with an IC50 of 41 nM. Samuraciclib displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2 (IC50 of 578 nM), CDK5 and CDK9, respectively. Samuraciclib inhibits the growth of breast cancer cell lines with GI50 values between 0.2-0.3 µM. Samuraciclib has anti-tumor effects.

We can also supply Samuraciclib intermediate:

3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol 771510-25-9;

5,7-dichloro-3-isopropylpyrazolo[1,5-a]pyrimidine 771510-32-8;

tert-butyl benzyl(5-chloro-3-isopropylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate 1092444-33-1;

(3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-ol 1805833-75-3;

(3R,4R)-tert-Butyl4-(aminomethyl)-3-(methoxymethoxy)piperidi ne-1-carboxylate 1805790-20-8;

N-Boc-4-(hydroxymethyl)-1,2,3,6-tetrahydropyridine 203663-26-7.

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.