Vidofludimus CAS 717824-30-1

Product Description:

Product Name:Vidofludimus CAS 717824-30-1

Synonyms:

2-[[(3-Fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid;

4SC-101.

Chemical & Physical Properties

Appearance:Light yellow crystalline solid

Assay: NLT98%

Boiling point:567.5°C

Density:1.354 g/cm3

chemical property :insoluble in H2O; insoluble in EtOH; ≥103 mg/mL in DMSO

Application: Vidofludimus, also known as 4SC 101 or SC12267, is a novel orally active and potent DHODH inhibitor. In vitro, 4SC-101 is a potent inhibitor of human DHODH, inhibits lymphocyte proliferation, and uniquely blocks phytohemagglutinin-stimulated IL-17 production by lymphocytes. In vivo, oral administration of 4SC-101 effectively improved both chronic DSS and acute TNBS colitis in mice. 4SC-101 may have potential for the treatment of intestinal inflammation. Dihydroorotate dehydrogenase (DHODH) is a key enzyme involved in pyrimidine biosynthesis. DHODH is a known target for the treatment of autoimmune diseases.

We can also supply Vidofludimus intermediate:

3-fluoro-3'-methoxy[1,1'-biphenyl]-4-amine 867287-99-8;

cyclopent-1-ene-1,2-dicarboxylic acid monomethyl ester 344751-62-8;

1-cyclopentene-1,2-dicarboxylic anhydride 3205-94-5.

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