Bortezomib CAS 179324-69-7

Product Description:

Product Name: Bortezomib CAS 179324-69-7

Synonyms:

3-methyl-1-((S)-3-phenyl-2-(pyrazine-2-carboxamido)propanamido)butylboronic acid;

B-[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(2-pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid;

Chemical & Physical Properties:

Appearance : White to Off-White Powder

Assay : ≥99.0%

Density: 1.214

Melting point: 122-124℃

PSA: 124.440

LogP: 2.45

Refractive Index: 1.564

Solubility: Soluble in chloroform, dimethyl sulfoxide, ethanol and methanol.

Stability: Hygroscopic and Moisture Sensitive

Category: Amines, Metabolites & Impurities, Nucleotides, Bases & Related Reagents,

Safety Information:

HS Code: 2934999090

Safety Phrases : S26-S36/37/39

RIDADR: 3261

RTECS NO: ED7771666

Storage:Hygroscopic, -20°C Freezer, Under Inert Atmosphere.

Application: 1.[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid is the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.

2. Bortezomib (PS-341) is a potent 20S proteasome inhibitor with a Ki of 0.6 nM.

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Inventory Status : In Stock.

We can provide CAS 179324-69-7 certificate of analysis( COA), N-[(1R)-1-(Dihydroxyboryl)-3-methylbutyl]-Nα-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide MOA, Bortezomib ROS, MSDS and other support for you !

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