Ibrutinib CAS NO 936563-96-1

Product Description:

Product Name: Ibrutinib CAS NO: 936563-96-1

Synonyms:

(R)-1-(3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one;

1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-one;

1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-but-3-en-1-one;

Chemical & Physical Properties:

Appearance : White to off-white powder.

Assay : ≥99.0%

Density: 1.34g/cm3

Melting point: 153-158℃

Boiling Point: 715.0℃ at 760 mmHg

Flash Point: 386.2℃

Refractive Index: 1.696

Vapor Pressure: 0.0mmHg at 25°C

PSA: 99.16000

LogP: 4.73640

Pka: 4.09

Solubility: DMSO : ≥ 30 mg/mL (68.10 mM), H2O : < 0.1 mg/mL (insoluble)

Chloroform (Slightly), Methanol (Slightly, Sonicated).

Category: Inhibitor; Inhibitors; Anticancer; Pharmaceutical/API Drug Intermediates;

Safety Information:

HS Code: 2933599090

Storage:Stored in a cool and dry well-closed container. Keep away from moisture and strong light/heat.

Application:

Ibrutinib is an oral inhibitor of Bruton’s tyrosine kinase that is used in the therapy of refractory chronic lymphocytic leukemia (CLL) and mantle cell lymphoma. Ibrutinib has not been associated with serum enzyme elevations during therapy, but has been linked to rare cases of clinically apparent acute liver injury and to reactivation of hepatitis B.

1-[(3R)-3-[4-Amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-2-propen-1-one is a highly selective Bruton’s tyrosine kinase (Btk) irreversible inhibitor.

Our factory manufacture’s Ibrutinib , mature technology, stable output, quality assurance.

Inventory Status : In Stock.

We can provide 2-Propen-1-one,1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]- COA (certificate of analysis), piperidin-1-yl]prop-2-en-1-one1-{3-[4-AMino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyriMidin-1-yl]-piperidin-1-yl}-propenone MOA (Method of Analysis), Ibrutinib(PCI-32765) ROS (Route of synthesis), 1-{3-[4-Amino-3-(4-phenoxy-phenyl)-pyrazolo[3,4-d]pyrimidin-1-yl]-piperidin-1-yl}-propenone MSDS (Material Safety Data Sheet) and other support for you !

In Vitro

Ibrutinib (PCI-32765) selectively inhibits B-cell signaling and activation. It inhibits autophosphorylation of Btk (IC50=11 nM), phosphorylation of Btk's physiological substrate PLCγ (IC50=29 nM), and phosphorylation of a further downstream kinase, ERK (IC50=13 nM)[1]. Ibrutinib (PCI-32765) inhibits BCR-activated primary B cell proliferation (IC50=8 nM). Following FcγR stimulation, Ibrutinib (PCI-32765) inhibits TNFα, IL-1β and IL-6 production in primary monocytes (IC50=2.6, 0.5, 3.9 nM, respectively).

In Vivo

Ibrutinib (PCI-32765) (3.125-50 mg/kg, p.o.) reduces the level of circulating autoantibodies and completely suppresses disease in mice with collagen-induced arthritis. Ibrutinib (PCI-32765) inhibits autoantibody production and the development of kidney disease in the MRL-Fas(lpr) lupus model. Ibrutinib (PCI-32765) (3.125-50 mg/kg, p.o.) reduces renal disease and autoantibody production in MRL-Fas(lpr) mice[1]. Ibrutinib (PCI-32765) (0.1 μM) inhibits activation-induced proliferation of CLL cells, induces selective cytotoxicity in B cells compared with T cells, but alters activation induced T-cell cytokine production[2]. Ibrutinib (PCI-32765) dose-dependently and potently reverses arthritic inflammation in a therapeutic CIA model with an ED50 of 2.6 mg/kg/day. Ibrutinib (PCI-32765) also prevents clinical arthritis in CAIA models.

we can supply Ibrutinib And Intermediates:

FAQ:

1. How to confirm the product quality before placing orders ?

a. We will offer you our products specification standard to you, and we test every batch of our product by HPLC, GC and HNMR and etc. We also cooperate with independent third party lab such as SGS,PONY etc.

b. Free samples of some products can be sent, only need to pay the shipping cost or arrange a courier to us and take the samples.

c. Send us your products specifications and requests, we will produce for you.

2. How to make order & payment ?

a. Proforma invoice will be sent after your confirmation of the order.

b. We can accept payment by T/T, L/C ,DA etc.

3. How to pack and storage ?

a. Packing: 1kg/Aluminum foil bag with Carton outside.

25kg/Fiber drum with double PE bags inside.

b. Storage: Store in cool & dry place, keep away from strong light and heat.

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Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.