Vecuronium Bromide CAS 50700-72-6 API Active Pharmaceutical Ingredient Powder

Product Description:

Product Name: Vecuronium bromide CAS NO:50700-72-6

Synonyms:

Vecuronium Bromide Hydrate;

(2β,3α,5α,16β,17β)-3,17-Diacetoxy-16-(1-methyl-1-piperidiniumyl)-2-(1-piperidinyl)androstane bromide;

Chemical & Physical Properties:

Appearance : White or off-white crystalline powder

Assay : ≥99.0%

Melting point: 227-229℃

Alpha:+30.5～+35.0゜(D/20℃)(c=0.5,dil.HCl)

solubility: Slightly soluble in water, freely soluble in methylene chloride, sparingly soluble in acetonitrile and in anhydrous ethanol.

Vecuronium bromide (Brand name: Norcuron) is a drug which can be supplied to general anesthesia to keep skeletal muscle relaxation during the surgery or mechanical ventilation. It can also be used to help with endotracheal intubation. It has rapid onset (within 4 minutes) and has its effect last for 4 hour.

Its mechanism of action is through competitively binding to the nicotinic cholinergic receptors, further antagonizing the opportunity for acetylcholine from binding to the nicotinic receptor at the postjunctional membrane of the myoneural junction. This process prevents the depolarization and the release of calcium ions, stopping muscle contraction and help muscle relaxation. Although vecuronium bromide is often thought of as a muscle relaxant, it may be more accurate to classify it as a paralyzing agent.

It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.

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