Rocuronium Bromide Powder CAS 119302-91-9 Active Ingredient API

Product Description:

Product Name: Rocuronium bromide CAS NO: 119302-91-9

Synonyms:

1-[(2b,3a,5a,16b,17b)-17-(Acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl]-1-(2-propenyl)pyrrolidinium Bromide;

Chemical & Physical Properties:

Appearance : White or off-white powder

Assay : ≥99.0%

Melting point: 162-164℃

Alpha: D20 +18.7° (c = 1.03 in CHCl3)

solubility: H2O: soluble100mg/mL, clear, light yellow.

Rocuronium is a derivative of vecuronium and has the same effect, but its strength is only 1/7. After intravenous injection, the effect is fast, intubation can be performed within 60 to 90 seconds, and the action lasts for 30 to 40 minutes. It has no obvious effect on autonomic nerve and cardiovascular, but it can reduce intraocular pressure without histamine release and sympathetic ganglion block.

Rocuronium and pancuronium, vecuronium, atracurium, and pipecuronium are currently several non-depolarizing muscle relaxants commonly used clinically in my country, and rocuronium has the fastest effect , It can provide ideal muscle relaxation conditions within 60-90s. After the non-depolarizing muscle relaxant binds to the cholinergic receptor of the motor end plate, it does not change the membrane potential of the motor end plate, but prevents the binding of acetylcholine to the receptor, and the muscle relaxes. Before the appearance of muscle relaxation, this type of medicine does not produce muscle twitches caused by muscle fiber bundle contraction like depolarizing muscle relaxants.

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