Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 955365-80-7
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
955365-80-7 |
Appearance:: |
Yellow Solid Powder |
Molecular Formula:: |
C27H32N8O2 |
Molecular Weight:: |
500.59 |
EINECS NO:: |
680-342-0 |
MDL NO:: |
MFCD17215200 |
CAS NO:: |
955365-80-7 |
Appearance:: |
Yellow Solid Powder |
Molecular Formula:: |
C27H32N8O2 |
Molecular Weight:: |
500.59 |
EINECS NO:: |
680-342-0 |
MDL NO:: |
MFCD17215200 |
Product Description:
Product Name: Adavosertib (MK-1775) CAS NO: 955365-80-7
Synonyms:
1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one;
2-allyl-1,8-dimethoxyanthracene-9,10-dione;
Chemical & Physical Properties:
Appearance: Yellow solid powder
Assay :≥99.0%
Density:1.293 g/cm3
Boiling Point:723.8℃ at 760 mmHg
Flash Point:391.5℃
Solubility: Soluble in DMSO.
MK-1775, also known as adavosertib, AZD-1775, is a WEE1 inhibitor, is also a small molecule inhibitor of the tyrosine kinase WEE1 with potential antineoplastic sensitizing activity. MK-1775 selectively targets and inhibits WEE1, a tyrosine kinase that phosphorylates cyclin-dependent kinase 1 (CDC2) to inactivate the CDC2/cyclin B complex. Inhibition of WEE1 activity prevents the phosphorylation of CDC2 and impairs the G2 DNA damage checkpoint. This may lead to apoptosis upon treatment with DNA damaging chemotherapeutic agents.
If you are interested in our products or have any questions, please feel free to contact us!
Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.
