Surufatinib CAS 1308672-74-3

Product Description:

Product Name: surufatinib CAS NO: 1308672-74-3

Synonyms:

KDR-IN-1;

EOS-61498;

HMPL012;

Chemical & Physical Properties:

Appearance: Off-white to white solid powder

Assay :≥98.0%

Density: 1.332±0.06 g/cm3 (Predicted)

Boiling point/range 712.9±70.0℃ at 760 mmHg

Flash point 385.0±35.7℃

Storage Condition: stored at 0-4℃ for a short period of time, a few days to a few months. The long term can be stored at -20℃ for three years. Store in a cool and dry place

Solubility: Soluble in DMSO

PKa: 5.22±0.40 (Predicted)

Safety Information:

Signal word: Danger

Hazard statements: H315/317/318/334/335/341/361/370/413

Incompatible materials: Strong acids/alkalis, strong oxidising/reducing agents

Hazardous decomposition products: Under fire conditions, may decompose and emit toxic fumes

Sulfatinib (HMPL-012, Sufatinib, Surfatinib) is a potent and highly selective tyrosine kinase inhibitor against VEGFR1, VEGFR2, VEGFR3, FGFR1 and CSF1R with IC50 of 2 nM, 24 nM, 1 nM, 15 nM and 4 nM, respectively. Sulfatinib shows encouraging antitumor activity and manageable toxicities in patients with advanced NETs.

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