Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 2097132-94-8
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
2097132-94-8 |
Appearance:: |
Crystalline Solid |
Molecular Formula:: |
C27H32FN9O2 |
Molecular Weight:: |
533.60000 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
CAS NO:: |
2097132-94-8 |
Appearance:: |
Crystalline Solid |
Molecular Formula:: |
C27H32FN9O2 |
Molecular Weight:: |
533.60000 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
Product Description:
Product Name: pralsetinib CAS NO: 2097132-94-8
Synonyms:
N-[(1S)-1-[6-(4-fluoropyrazol-1-yl)pyridin-3-yl]ethyl]-1-methoxy-4-[4-methyl-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]cyclohexane-1-carboxamide;
(1s,4R)-N-((S)-1-(6-(4-fluoro-1H-pyrazol-1-yl)pyridin-3-yl)ethyl)-1-methoxy-4-(4-methyl-6-((5-methyl-1H-pyrazol-3-yl)amino)pyrimidin-2-yl)cyclohexane-1-carboxamide;
Chemical & Physical Properties:
Appearance: Crystalline solid
Assay: ≥99.0%
Density: 1.40±0.1 g/cm3(Predicted)
Bolting Point: 799.1±60.0 ℃(Predicted)
Storage Conditions: -20℃
Solubility: DMSO ≥ 80 mg/mL
BLU-667 (Pralsetinib) is a highly potent and selective, next generation RET inhibitor with IC₅₀ of 0.3-0.4 nM for WT RET, RET mutants V804L, V804M, M918T and CCDC6-RET fusion. In vivo, BLU-667 potently inhibits growth of NSCLC and thyroid cancer xenografts driven by various RET mutations and fusions without inhibiting VEGFR2.
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