Baricitinib CAS 1187594-09-7

Product Description:

Product Name: baricitinib CAS NO: 1187594-09-7

Synonyms:

2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile;

{1-(ethylsulfonyl)-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]azetidin-3-yl}acetonitrile;

3-Azetidineacetonitrile,1-(ethylsulfonyl)-3-(4-(7H-pyrrolo(2,3-d)pyrimidin-4-yl)-1H-pyrazol-1-yl);

Chemical & Physical Properties:

Appearance: Light yellow powder

Assay: ≥99.0%

Density: 1.6±0.1 g/cm3

Flash Point: 381.5±35.7 ℃

Bolting Point: 707.2±70.0℃at 760 mmHg

Refractive Index: 1.763

Safety Information:

Signal word: Warning

Hazard statements: H302

Baricitinib is a JAK1 and JAK2 inhibitor and have been used as a promising treatment for rheumatoid arthritis.

2-(3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-1-(ethylsulfonyl)azetidin-3-yl)acetonitrile is indicated for the treatment of moderate to severe active rheumatoid arthritis in adult patients who have responded inadequately to, or who are intolerant to one or more disease-modifying anti-rheumatic drugs as monotherapy or in combination with methotrexate.

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