Larotrectinib CAS 1223403-58-4

Product Description:

Product Name: larotrectinib CAS NO: 1223403-58-4

Synonyms:

LOXO-101;

Larotrectinib free base;

(S)-N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide;

Chemical & Physical Properties:

Appearance: White to yellow solid

Assay: ≥99.0%

Density: 1.55±0.1 g/cm3 (Predicted)

Refractive Index: 1.725

Storage Conditions: -20℃

Solubility:DMSO : ≥ 4.6 mg/mL (10.74 mM)

Safety Information:

Signal Word: Warning

Hazard Statements: H315/319/335

Precautionary Statements: P261/P305+351+338/P302+352

Larotrectinib (VITRAKVIR) is an orally administered, small molecule, highly-selective, tropomyosin receptor kinase (TRK) inhibitor that was developed by Loxo Oncology in collaboration with Bayer AG as a treatment for adult and paediatric patients whose cancers harbour neurotrophic receptor tyrosine kinase (NTRK) gene fusions.

Larotrectinib is a highly selective, potent inhibitor of TRKA, TRKB and TRKC (in vitro 50% inhibitory constant 5–11 nmol/L), with minimal or no activity against other kinase and non-kinase targets [1, 2]. Inhibition of TRKs prevents TRK activation, resulting in both the induction of cellular apoptosis and the inhibition of cell growth in tumours that overexpress TRKs.

we can supply Larotrectinib CAS:1223403-58-4 intermediates.

(R)-2-(2,5-Difluorophenyl)pyrrolidine CAS 1218935-59-1
(R)-2-(2,5-Difluorophenyl)pyrrolidine hydrochloride CAS 1218935-60-4
5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3,5-dihydropyrazolo[1,5-a]pyrimidin-3-amine CAS 1223404-88-3
5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3,5-dihydropyrazolo[1,5-a]pyrimidine CAS 1223404-89-4
(R)-5-(2-(2,5-difluorophenyl)pyrrolidin-1-yl)-3-nitropyrazolo[1,5-a]pyrimidine CAS 1223404-90-7
5-Hydroxypyrazolo[1,5-a]pyrimidine; Pyrazolo[1,5-a]pyrimidin-5-ol; 4H,5H-pyrazolo CAS 29274-22-4
5-Chloropyrazolo[1,5-a]pyrimidine CAS 29274-24-6
(R)-tert-butyl 2-(2,5-difluorophenyl)pyrrolidine-1-carboxylate CAS 1218935-58-0
5-Chloro-3-nitropyrazolo[1,5-a]pyrimidine CAS 1363380-51-1
(R)-2-(2,5-difluorophenyl)pyrrolidine (R)-2-hydroxysuccinate CAS 1919868-77-1
tert-butyl 4-(4-methylpiperazin-1-yl)-2-nitrobenzoate CAS 942271-61-6

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