Risdiplam CAS 1825352-65-5

Product Description:

Product Name: risdiplam CAS NO: 1825352-65-5

Synonyms:

2-(4,6-dimethylpyrrolo[1,2-b]pyridazin-2-yl)-7-(4,7-diazaspiro[2.5]octan-7-yl)-4H-pyrido[1,2-a]pyrimidin-4-one;

Chemical & Physical Properties:

Appearance: Light yellow powder to yellow powder

Assay: ≥99.0%

Density: 1.29±0.1 g/cm3 (Predicted)

Solubility: DMSO: < 1 mg/mL (insoluble or slightly soluble)(< 1 mg/ml refers to the product slightly soluble or insoluble )

Storage: 0-4℃ for short term (days to weeks) or -20℃ for long term (months)

Risdiplam (RG7916; RO7034067) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels.

Risdiplam modulates SMN2 pre-mRNA splicing towards the production of full-length SMN2 mRNA and increases SMN protein levels. Risdiplam is a modifier of SMN2 splicing, leading to an increase in SMN2 full length transcript and thus functional SMN protein. Spinal muscular atrophy (SMA) type I remains the most common genetic disease resulting in death in infancy. Characterized by progressive motor and respiratory muscle weakness, this autosomal recessive neuromuscular disorder is caused by low levels of the survival motor neuron protein (SMN) due to inactivating bi-allelic deletions and other disabling mutations in the survival motor neuron 1 (SMN1) gene.

we can supply Risdiplam intermediate:

CAS: 1825352-86-0,2,8-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazine

CAS:1449598-86-0,2-chloro-7-fluoro-4H-pyrido[1,2-a]pyrimidin-4-one

CAS:145122-56-1, 4,7-Diaza-spiro[2.5]octane dihydrochloride

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.