Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1492952-76-7
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
1492952-76-7 |
Appearance:: |
Crystalline Solid |
Molecular Formula:: |
C20H18ClF2N5O3 |
Molecular Weight:: |
449.83800 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
CAS NO:: |
1492952-76-7 |
Appearance:: |
Crystalline Solid |
Molecular Formula:: |
C20H18ClF2N5O3 |
Molecular Weight:: |
449.83800 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
Product Description:
Product Name: asciminib CAS NO: 1492952-76-7
Synonyms:
ABL001;
ASCIMINIB;
ASCIMINIB FREE BASE;
Chemical & Physical Properties:
Appearance: Crystalline solid
Assay: ≥98.0%
Density: 1.5±0.1 g/cm3
Boiling Point: 631.7±55.0℃ at 760 mmHg
Flash Point: 335.8±31.5 ℃
Refractive Index: 1.662
Storage Conditions: -20℃
Asciminib, also known as ABL001, is a potent allosteric inhibitor of BCR-ABL. ABL001 prevents emergence of resistant disease when administered in combination with nilotinib in an in vivo murine model of chronic myeloid leukemia. Cell proliferation studies demonstrate that ABL001 selectively inhibited the growth of CML and Ph+ ALL cells with potencies ranging from 1-10nM range. ABL001 was tested for activity against clinically observed mutations and found to be active in the low nM range. In the KCL-22 mouse xenograft model, ABL001 displayed potent anti-tumor activity with complete tumor regression observed and a clear dose-dependent correlation with pSTAT5 inhibition.
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