Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1100598-32-0
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
1100598-32-0 |
Appearance:: |
Off-white To Pale Beige Solid |
Molecular Formula:: |
C29H28N6O2 |
Molecular Weight:: |
492.57200 |
EINECS NO:: |
NA |
MDL NO:: |
MFCD18452823 |
CAS NO:: |
1100598-32-0 |
Appearance:: |
Off-white To Pale Beige Solid |
Molecular Formula:: |
C29H28N6O2 |
Molecular Weight:: |
492.57200 |
EINECS NO:: |
NA |
MDL NO:: |
MFCD18452823 |
Product Description:
Product Name: tepotinib CAS NO: 1100598-32-0
Synonyms:
3-(1-(3-(5-(1-methylpiperidin-4-ylmethoxy)pyrimidin-2-yl)benzyl)-1,6-dihydro-6-oxopyridazin-3-yl)benzonitrile;
EMD 1214063;
Chemical & Physical Properties:
Appearance: Off-white to pale beige solid
Assay: ≥99.0%
Density: 1.25
Flash Point: 332.7±34.3℃
Boiling Point: 626.5±65.0℃(Predicted)
Vapour Pressure: 0.0±1.8 mmHg at 25℃
Index of Refraction: 1.660
Tepotinib is a highly selective inhibitor against MET. In xenograft models, acquired resistance to EGFR TKIs via secondary EGFR T790 M mutations can be overcome with tepotinib treatment. EMD 1214063 is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. IC50 Value: 4 nM [1]Target: c-Metin vitro: EMD 1214063 inhibits HGF-induced c-Met phosphorylation in A549 cells with IC50 of 6 nM.
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