Product Details
Place of Origin: China
Brand Name: Sunshine
Certification: ISO,COA
Model Number: 1847461-43-1
Payment & Shipping Terms
Minimum Order Quantity: Negotiation
Price: Negotiation
Packaging Details: Aluminum Foil Bag, Drum
Delivery Time: 7-15 days
Payment Terms: T/T, L/C, D/A, Western Union
Supply Ability: TON
CAS NO:: |
1847461-43-1 |
Appearance:: |
Pale Yellow Solid Powder |
Molecular Formula:: |
C32H39N7O4 |
Molecular Weight:: |
585.70 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
CAS NO:: |
1847461-43-1 |
Appearance:: |
Pale Yellow Solid Powder |
Molecular Formula:: |
C32H39N7O4 |
Molecular Weight:: |
585.70 |
EINECS NO:: |
NA |
MDL NO:: |
NA |
Product Description:
Product Name: mobocertinib CAS NO: 1847461-43-1
Synonyms:
AP 32788;
TAK-788;
Chemical & Physical Properties:
Appearance: Pale yellow solid powder
Assay: ≥99.0%
Solubility: DMSO ≥ 8 mg/Ml
Storage: at -20℃
Safety Information:
Signal Word: Warning
Hazard Statements: H302; H315; H319; H335
Precautionary Statements: P261; P305+P351+P338
Mobocertinib (TAK-788) is an investigational TKI with potent, selective preclinical activity against activating EGFR and HER2 mutations, including exon 20 insertions. Mobocertinib (TAK-788) inhibits all 14 mutant variants of EGFR (IC50s=2.4-22 nM), and all 6 mutant variants of HER2 (IC50s=2.4-26 nM), more potently than it inhibited WT EGFR (IC50=35 nM). Daily oral dosing of Mobocertinib in mice implanted with a patient-derived tumor containing an EGFR exon 20 activating insertion induced regression of tumors at doses that were well tolerated (30-100 mg/kg).
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