Allopurinol CAS 315-30-0

Product Description:

Product Name: Allopurinol CAS NO: 315-30-0

Synonyms:

Pural; Apurin;4-HPP;Anzief;HPP;

1H-Pyrazolo[3,4-d]pyrimidin-4(5H)-one;

4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro-;

aloral; 4-Hydroxypyrazolo[3,4-d]pyrimidine;

Apurol;Allopurinol;Remid;Urbol;

1H-Pyrazolo[3,4-d]pyrimidin-4-ol;

1H-Pyrazolo(3,4-d)pyrimidin-4-ol (4-Hydroxypyrazolo(3,4-d)pyrimidine;

allopurinal;

Chemical & Physical Properties:

Appearance : White to Off-White powder

Assay : ≥99.0%, GMP/DMF

Density                         1.89g/cm3

Boiling Point                 290.8ºC at 760 mmHg

Melting Point                350ºC

Flash Point                   129.7ºC

Refractive Index           1.816

Water Solubility             0.35 g/L (25 ºC)

Stability                         Stable under normal temperatures and pressures.

Storage Condition         Store in a tightly closed container. Store in a cool, dry area away from incompatible substances.

Safety Info

RTECS                          UR0785000

Hazard Class                 6.1

Safety Statements         S24-S26-S36/37/39-S45

HS Code                        2933990090

Packing Group               III

WGK Germany               2

RIDADR                         UN 2811

Risk Statements             R25; R36/37/38; R43

Hazard Codes                T

Symbol                           GHS06

Hazard Declaration        H301; H317

Signal Word                    Danger

Caution Statement          P280; P301 + P310

Allopurinol, sold under the brand name Zyloprim and generics, is a medication used primarily to treat excess uric acid in the blood and its complications, including chronic gout. It is a xanthine oxidase inhibitor and is administered orally.

It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.

Allopurinol (Zyloprim) is a xanthine oxidase inhibitor with an IC50 of 7.82±0.12 μM.Target: XAOAllopurinol (Zyloprim, and generics) is a drug used primarily to treat hyperuricemia (excess uric acid in blood plasma) and its complications, including chronic gout. It is a xanthine oxidase inhibitor which is administered orally. A common misconception is that allopurinol is metabolized by its target, xanthine oxidase, but this action is principally carried out by Aldehyde oxidase. The active metabolite of allopurinol is oxypurinol, which is also an inhibitor of xanthine oxidase. Allopurinol is almost completely metabolized to oxypurinol within two hours of oral administration, whereas oxypurinol is slowly excreted by the kidneys over 18–30 hours. For this reason, oxypurinol is believed responsible for the majority of allopurinol's effect.Allopurinol is a purine analog; it is a structural isomer of hypoxanthine (a naturally occurring purine in the body) and is an inhibitor of the enzyme xanthine oxidase. In addition to blocking uric acid production, inhibition of xanthine oxidase causes an increase in hypoxanthine and xanthine. While xanthine cannot be converted to purine ribotides, hypoxanthine can be salvaged to the purine ribotides adenosine and guanosine monophosphates. Increased levels of these ribotides may cause feedback inhibition of amidophosphoribosyl transferase, the first and rate-limiting enzyme of purine biosynthesis. Allopurinol, therefore, decreases uric acid formation and may also inhibit purine synthesis.

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