Ebastine CAS NO: 90729-43-4

Product Description:

Product Name: Ebastine CAS NO: 90729-43-4

Synonyms:

4-(4-benzhydryloxypiperidin-1-yl)-1-(4-tert-butylphenyl)butan-1-one;

Ebastinum [Latin];

[14C]-Ebastine;

carebastine;

4-diphenylmethoxy-1-[3-(4-tert-butylbenzoyl)propyl]-piperidi ne;

ebastine;

Kestine;

Ebastel;

Estivan;

Ebastin;

Chemical & Physical Properties:

Appearance : white to off-white crystalline powder

Assay : ≥99%

Density:1.09 g/cm3

Melting Point:80-82℃

Boiling Point:569.3℃ at 760 mmHg

Flash Point:314.5℃

Solubility:Slightly soluble in chloroform, methanol.

Ebastine belongs to an effective second generation histamine H1 receptor antagonist. One important property of it is that it doesn’t penetrate the blood brain barrier. Therefore, it is capable of blocking the H1 receptor in peripheral tissue without having some specific side effects such as sedation and drowsiness. Ebastine is mainly applied for the treatment of allergic rhinitis, pruritus as well as acting as an alternative drug in Decongestant. Upon entering into the human body, it can subject to the action of hepatic cytochrome P450 3A4 to be converted to an active carboxylic acid metabolite, carebastine. The later one is the major active form in vivo. Under certain range, it can inhibit T cell proliferation and the production of Th2-type pro-inflammatory cytokines through macrophages. Ebastine generally has a high safety property without causing cognitive/psychomotor impairment and sedation, like placebo. However, it can cause side effects such as inflammation of the air-cavities around nose, sore throat, indigestion, nausea, headache, and abdominal pain.

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.