Flurbiprofen CAS 5104-49-4

Product Description:

Product Name: flurbiprofen CAS NO: 5104-49-4

Synonyms:

2-(2-fluoro-4-biphenylyl)propionicacid;

2-fluoro-alpha-methyl-4-biphenylaceticacid;

2-(2-Fluorobiphenyl-4-yl)propionic Acid;

Chemical & Physical Properties:

Appearance: White to off-white crystalline solid

Assay :≥98%

Density: 1.279 g/cm3 (25℃)

Boiling Point: 376℃

Melting Point: 110-112℃(lit.)

Stability: Stable at normal temperatures and pressures

Storage Condition: Keep tightly closed

Water Solubility: 8mg/L(room temperature)

Solubility: Methanol: soluble50mg/mL

Safety Information:

Signal Word: Danger

Symbol: GHS06

Safety Statements: S36/37/39-45

Hazard Class: 6.1(b)

Hazard Codes: T; C

HS Code: 2916399090

Packing Group: III

WGK Germany: 3

RTECS: DU8341000

RIDADR: UN 2811 6.1/PG 2

Risk Statement: R25

Hazard Declaration: H301

Caution Statements: P301 + P310

Flurbiprofen synthesis was originally reported in 1974. During a study of the pharmacological properties of a large number of substituted phenylalkanoic acids, including ibuprofen and ibufenac, the most potent were found to be substituted 2-(4-biphenyl)propionic acids. Further toxicological and pharmacological studies indicated that flurbiprofen possessed the most favorable therapeutic profile, so it was selected for further clinical development. It was not marketed until 1987, when it was introduced as the sodium salt as Ocufen, the first topical NSAID indicated for ophthalmic use in the United States. The indication for Ocufen is the same as that for Profenal—that is, to inhibit intraoperative miosis induced by prostaglandins in cataract surgery.

2-(2-fluoro-4-biphenylyl)propionicacid is anti-inflammatory drug for chronic arthritis and pain, inflammation of Deformation joint disease, and pain after surgery and tooth extraction. Mouse oral LD50 of 140mg/kg, rats 640-800mg/kg.

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