Fasudil Hydrochloride CAS 105628-07-7

Product Description:

Product Name: Fasudil Hydrochloride CAS NO: 105628-07-7

Synonyms:

5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline hydrochloride;

1-(5-Isoquinolinesulfonyl)homopiperazine Hydrochloride;

5-(1-Homopiperazinyl)sulfonylisoquinoline Hydrochloride;

Chemical & Physical Properties:

Appearance: White solid

Assay :≥99%

Flash Point: 259.9℃

Boiling Point: 506.2℃ at 760 mmHg

Melting Point: 220.5℃; mp 219.3℃ (Shirotani)

Solubility: H2O: >200 mg/mL

Water Solubility: Soluble in water and dimethyl sulfoxide. Insoluble in ethanol.

Safety Information:

HS Code: 2942000000

Risk Statement: R22

Safety Statements: S36-60

WGK Germany: 3

Hazard Statement: H302

Precautionary Statements: P264+P270+P301+P312+P330+P501

Fasudil hydrochloride, a novel calcium antagonistic vasodilator, was marketed for the treatment of cerebral vasospasm following subarachnoid hemorrhage (SAH). Fasudil is also a potent inhibitor of myosin light chain kinase and protein kinase C. In contrast to other calcium channel blockers, which regulate the influx of calcium ions through the cell membrane but not involved in the intracellular regulatory mechanism of the calcium, fasudil was suggested to have an intracellular mode of action in relaxing vascular smooth muscle. In patients with neurological deficits due to vasospasm, fasudil decreased the occurrence of angiographic severe and symptomatic vasospasm and cerebral infarction without decreasing systemic blood pressure. Fasudil is reportedly in clinical trials for acute ischemic stroke, sequelae of cerebral vascular diseases and angina pectoris.

If you are interested in our products or have any questions, please feel free to contact us!

Products under patent are offered for R & D purpose only. However, the final responsibility lies exclusively with the buyer.