Mefloquine HCl CAS 51773-92-3 API Active Pharmaceutical Ingredient

Product Description:

Product Name: Mefloquine HCl CAS NO: 51773-92-3

Synonyms:

2,8-bis(trifluoromethyl)-alpha-2-piperidinyl-4-quinolinemethanomonohydroch;

dl-erythro-alpha-(2-piperidyl)-2,8-bis(trifluoromethyl)-4-quinolinemethanol;s*)-(r(+-)-lorid;

Mefloquin hydrochloride;

Chemical & Physical Properties:

Appearance: Off-white to yellow solid

Assay :≥99%

Density: 1.383g/cm3

Boiling Point: 415.7℃ at 760mmHg

Melting Point: 250-254℃

Flash Point: 205.2℃

Stability: Stable at normal temperatures and pressures

Storage Condition: Store only in the original container. Keep container tightly sealed.

Water Solubility: DMSO: 38 mg/mL, soluble

Safety Information:

RTECS: VC0308000

WGK Germany: 3

Risk Statement: R22

Hazard Code: Xn

Symbol: GHS07

Signal Word: Warning

Hazard Declaration: H302

Precautionary Statements: P301 + P312 + P330

Mefloquine hydrochloride is a quinoline antimalarial drug that is structurally related to the antiarrhythmic agent quinidine. IC50 Value: 1 microM ( for K+ channel)Target: AntiparasiticMefloquine is widely used in both the treatment and prophylaxis of Plasmodium falciparum malaria. MQ can induces oxidative stress in vitro. Evidence indicates that reactive oxygen species (ROS) may be used as a therapeutic modality to kill cancer cells [2].in vitro: Mefloquine inhibitedKvLQT1/minK channel currents with an IC50 value of approximately 1 microM. Mefloquine slowed the activation rate of KvLQT1/minK and more block was evident at lower membrane potentials compared with higher ones. HERG channel currents were about 6-fold less sensitive to block by mefloquine (IC50 = 5.6 microM). Block of HERG displayed a positive voltage dependence with maximal inhibition obtained at more depolarized potentials [1]. MQ has a highly selective cytotoxicity that inhibits PCa cell growth. MQ-mediated ROS simultaneously downregulated Akt phosphorylation and activated extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK) and adenosine monophosphate-activated protein kinase (AMPK) signaling in PC3 cells . in vivo: Pregnant rats were treated orally with AS (15 and 40 mg/kg body weight (bwt)/day), MQ (30 and 80 mg/kg bwt/day) and AS/MQ (15/30 and 40/80 mg/kg bwt/day) on days 9-11 post coitum (pc). The dams were euthanized on day 12 pc and gestational and embryos histological parameters were evaluated.Clinical trial: Activity of Mefloquine against Urinary Schistosomiasis.

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